Charlie, I am now 48, was diagnosed with PD 13yrs ago, initially taking just Symetrell. About 18 months later started Sinemet, 10/100. Like you I didn't see a dramatic change, except in freeing up my handwriting. I had hit and miss bouts of nausea with the 10/100, never actually vomited, but would get the cold sweats and get right to brink, then it would pass. I found splitting dose around a glass of milk with toast, donut, cookies etc. helped. Over the next few years I gradually went up to Sinemet 25/250("Blue Bastards") and for about 2 years, the second one of the day would incapacitate me for about 10 minutes with waves of nausea and cold sweats, again I never actual got sick. Again splitting dose around food helped, but did not eliminate problem. Time helped, and then when Parlodel(now Permax) and Eldepryl were added to my "stew", Sinemet dose went down to 25/100 and I can't remember ever getting nauseated since. I had what must have been "smell hallucinations" for about 6-9 months when I first started taking Eldepryl. Suddenly I constantly smelled "old sneaker" or "gym locker" odor. I was convinced that the PD sweats were causing this BO. I felt like the "UN-SURE" guy in the commercial. I asked my wife and she could not smell it. Nor could anybody else, including the neurologist who said it must have been triggered by the Eldepryl. But boy it sure smelled real to me! And then it stopped and has never returned. And it was only this one type smell, never anything else. Good luck and welcome to "Network", lots of good people, lots of good info. Stephen Holahan([log in to unmask])