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Blackouts & PD The most common cause of blackout is hypotension.. low blood pressure,,,,Orthostatic in particular which is occasioned by standing too rapidly. Sinemet & eldepryl both list hypotension as likely side effects & hypotension can go with PD by itself. Blackouts usually last very short periods of time, but may seem quite long.... I passed out in December (blackout) and was out maybe 5 seconds but I could have been out a half hour for all I knew.