This is in response to J. R. Newbrough & tangential to Stephen Holahan: According to the experts at Graduate Hospital, Philadelphia, the sense of smell is not affected by Sinemet therapy. This has been repeated and referenced to itself several times. We on the cold end of the stethocope often know better than the experts. I took the Univ. of Pennsylvania Smell Identification Test (UPSIT) and although it seemed quite naive to me is the gold [all that glittters..read pot metal] stadard for olfactory testing. Smell technology is lagging. In my case, I have no automatic awareness of being "on" following a Sinemet dose such as a "rush" feeling mentioned primarily by neurologists. I can tell when I am "on" automatically by becoming aware of certain smells. [Motor skills are determined by whether I can perform a certain task or not-- not automatic}. The smell that I lose when "off" is sharp & acrid. I use merely acrid. I do not smell auto exhaust (diesel yes), vile odors from beauty parlors giving permanent waves, many paints drying, many organic solvents, barely smell mercaptan, cheap zScotch tastes good, skunk smells sweet. With s dose of Sinemet these things come back. Sometimes I think being "off" has advantages. Will Johnston, Salisbury, Maryland (a former Tennessean whose mottther worked on the Nashville Banner following her 1 year at Vandy in ~1924.