Charles: Sorry for the late reply; i was out of town for two weeks. I am 27, diagnosed 2 1/2 years, taking Sinemet the entire time. I have found that taking Sinemet either half-an-hour prior or one hour after eating works best for me (as suggested by Alan Bonander on this list). I rarely have nausea. Of course, it depends on how much protein you eat as to how well the meds work. I take Sinemet CR. I take 1 whole Sinemet with one Eldepryl for my first dose, then a half Sinemet every two hours four times a day. I have recently cut out caffeine from my diet and have noted less dyskinesia. Peace, On 4/6/95, Charlie Barasch ([log in to unmask]) wrote: > I was diagnosed with PD two years ago, but have just started >taking sinemet, after two years of just eldepryl. My symptoms >are still fairly mild, and only slightly more advanced than two >years ago, but my neurologist told me I'd feel a lot better with >the sinemet, so I thought I'd try it. I think that based on what >he said, I was expecting a "Popeye and spinach" effect, but >after two weeks on sinemet 25-100, I notice only small changes, >and I'm not even sure about those. My balance certainly seems >better -- getting in and out of chairs is a lot easier. That >seems to be the biggest change. I think my foot-dragging, lack >of armswing, and difficulty putting my sweater on are better, >but I'm not sure. Other people tell me I seem more animated, >even those who didn't know I'd started sinemet. I also have some >side effects. I know that most of you on this network have used >sinemet a lot longer than me, so I thought I'd ask some >questions: > >1) Is my response to sinemet fairly typical? > >2) One of my side effects is nausea, especially in the morning. >I'm taking 3 pills a day, with breakfast, lunch and dinner. I >sometimes get nausea about 30 minutes after taking the morning >pill, sometimes also after the others. Any suggestions? Should >I take it before, during, or after the meal? (My neurologist >suggests before; he also said I might try taking half the pill >before, and half after.) Rom Carpathian [persona] ([log in to unmask]) Jeffrey Romanyshyn Ph.D. Student-Humanities "The darkest hour is just before dawn" "When two Vampyres fall in love in Cyberspace, it's called: Love at first Byte!" Rom Carpathian