Here's a few more that I've downloaded from the WWW: (see enclosures) Wendy T. <<<<<< Attached TEXT file named "Chinese pd patients" follows >>>>>> Debrisoquine metabolism in Chinese patients with Alzheimer's and Parkinson's diseases. Liu TY; Chi CW; Yang JC; Cheung SC; Liu HC Department of Medical Research, Veterans General Hospital-Taipei, Taiwan, ROC. Mol Chem Neuropathol 17: 31-7 (1992) Abstract We determined the oxidative phenotype and metabolic ratio of debrisoquine in 96 Chinese patients with Alzheimer's disease (n = 12), Parkinson's disease (n = 55), and using patients with stroke and cervical spondylosis as controls (n = 29). We did not find any difference in debrisoquine metabolic phenotype among Parkinson's disease, Alzheimer's disease, and control patients as judged by chi-square analysis. In addition, the metabolic ratio of all our patients was less than 12.6. The result suggested that Chinese patients with Parkinson's disease and Alzheimer's disease metabolize debrisoquine at a velocity not different from that of their Western counterparts even though the frequency distribution of debrisoquine metabolism phenotyping in these two populations is quite different. Mesh Headings Aged Alzheimer's Disease* China Debrisoquin* Female Human Male Oxidation-Reduction Parkinson Disease* Phenotype Unique Identifier: 93000132 Chemical Identifiers (Names) 1131-64-2 (Debrisoquin) <<<<<< Attached TEXT file named "debrisoquine oxidation?" follows >>>>>> Debrisoquine oxidation in Parkinson's disease. Kallio J; Marttila RJ; Rinne UK; Sonninen V; Syvalahti E Department of Pharmacology, University of Turku, Finland. Acta Neurol Scand 83: 194-7 (1991) Abstract Variations in the activities of xenobiotic metabolizing liver enzymes may be involved in the pathophysiology of diseases, including Parkinson's disease. We therefore studied the activity of the debrisoquine metabolizing enzyme in 97 patients with newly diagnosed Parkinson's disease. The urine debrisoquine metabolic ratios (MR) of the patients were compared with a group of 176 healthy subjects. There were 4 poor metabolizers (4.1%) among the parkinsonians. This proportion did not differ from that found in the group of healthy subjects (51%). In contrast to earlier finding, the parkinsonian poor metabolizers (PM) had the onset of the disease later than the parkinsonian extensive metabolizers (EM). In the parkinsonian patients, it was observed that the excretion of debrisoquine and 4-OH-debrisoquine into urine correlated inversely with the actual age and age at disease onset. Our results indicate that in patients with Parkinson's disease, debrisoquine hydroxylation is comparable with healthy subjects. Mesh Headings Adult Aged Aged, 80 and over Cytochrome P-450* Debrisoquin* Female Human Hydroxylases* Male Middle Age Parkinson Disease* Phenotype Support, Non-U.S. Gov't Unique Identifier: 91233817 Chemical Identifiers (Names) EC 1.14. (Hydroxylases) EC 1.14.99.- (debrisoquine 4-hydroxylase) 1131-64-2 (Debrisoquin) 9035-51-2 (Cytochrome P-450) <<<<<< Attached TEXT file named "etiology of pd" follows >>>>>> Etiology of Parkinson's disease: current concepts. Duvoisin RC Clin Neuropharmacol 9 Suppl 1: S3-21 (1986) Abstract The etiology of Parkinson's disease remains an enigma. Yet substantial progress toward its elucidation has been made in recent years. This disease has emerged as a particular morbid entity with a characteristic pathology and clinical expression. Viral encephalitis and heredity, which have long dominated discussions of the possible causes of the disease, appear to have been excluded. However, the possibility of a viral or subviral pathogen as the causative factor has not been excluded. The discovery of a selective dopaminergic neurotoxin, MPTP, which is active via any portal of entry, has raised the question of a toxic etiology. Current attention has focused on the search for an environmental agent. Recent studies of the Lewy body, the pathologic hallmark of Parkinson's disease, point to possible defects in neurofilament synthesis or transport. The finding that cultured cells from patients with Parkinson's disease have an abnormal radiosensitivity suggests that an acquired defect in DNA repair mechanisms may play a role. Mesh Headings Atrophy Brain Cerebral Palsy DNA Repair Eosin Human Intermediate Filaments Parkinson Disease* Pyridines Review Stains and Staining Virus Diseases Unique Identifier: 86217829 Chemical Identifiers (Names) 28289-54-5 (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) 548-26-5 (Eosin) <<<<<< Attached TEXT file named "International Congress on Hazar" follows >>>>>> [Image] Agency for Toxic Substances and Disease Registry Public Health Service U.S. Department of Health and Human Services ------------------------------------------------------------------------ Announces: The International Congress on Hazardous Waste: Impact on Human and Ecological Health Atlanta Marriott Marquis Hotel Atlanta, Georgia June 5-8, 1995 ------------------------------------------------------------------------ A Visitor's Guide to Atlanta - Courtesy of T.R.A.V.E.L.I.N.K inc. and Georgia Tech ------------------------------------------------------------------------ Congress Announcement The Agency for Toxic Substances and Disease Registry announces the "International Congress on Hazardous Waste: Impact on Human and Ecological Health" to be held at the Atlanta Marriott Marquis Hotel, June 5-8, 1995, in Atlanta, Georgia. The purpose of this Congress is to promote the exchange of findings, ideas, and recommendations related to the human and ecological health effects of hazardous waste. The intended audience includes environmental epidemiologists, toxicologists, ecologists, health scientists, and environmental engineers from both government and academic settings; clinical and public health physicians working in environmental and occupational health; health educators; public health administrators and policy makers; health, safety, and management representatives from industry; professional environmentalists; and the interested general public. Sponsors Agency for Toxic Substances and Disease Registry, Association of Occupational and Environmental Clinics, Association of Schools of Public Health, Chemical Manufacturers Association, Clean Sites, Emory University School of Public Health, Environmental Defense Fund, International Association for Clean Technology, International Chemical Workers, International Life Sciences Institute, International Programme on Chemical Safety (through the World Health Organization, the United Nations Environmental programs, and the International Labor Organization), International Society for Exposure Analysis, Laborers' Health & Safety Fund of North America, National Center for Environmental Health of the Centers for Disease Control and Prevention, National Institute of Environmental Health Sciences of the National Institutes of Health, National Institute for Occupational Safety and Health of the Centers for Disease Control and Prevention, National Resources Defense Council, Pan American Health Organization, Sierra Club, United Nations Environmental Programme, United Nations Industrial Development Organization, U.S. Environmental Protection Agency, and the World Wildlife Fund. Registration Information Congress Registration may be completed by sending name, position/title, organization, name to be listed on the name badge, mailing address, telephone, FAX number, and a check for $200 made out to Emory University School of Public Health ($150 if Registered by May 15), to Emory University School of Public Health, Division of Environmental and Occupational Health, International Congress on Hazardous Waste, 1599 Clifton Road, N.E., Atlanta, Georgia 30329. Attention: Dr. Howard Frumkin. Please indicate if you are disable or you have a condition that requires either special assistance or accommodations. You may print this message with the attached Registration Form. Full-Time Matriculating Students may register for $100 ($50 if Registered by May 15). Call 404-639-0708 if you need any other information. Hotel Information A block of rooms has been reserved at the Marriott Marquis Hotel, 265 Peachtree Center Avenue, Atlanta, Georgia, 30303. The Marriott Marquis Hotel features a 50-story interior atrium designed by world-renowned architect, John Portman. It is located in the heart of downtown Atlanta's prestigious Peachtree Center. The hotel has ten restaurants and lounges, an indoor/outdoor pool, a fully- equipped health club, and a collection of boutiques. The hotel warrants that it is in compliance with the Americans with Disabilities Act (Public Law 101-336) and that it will comply in all respects with the provisions of the Act and regulations issued thereunder. Lodging rates for attendees is $81.00 (tax included) per day. Smoke-Free Environment In keeping with applicable local ordinances, and public health practice, Congress meeting spaces will be smoke free. Fragrance Alert Congress attendees are requested to be mindful of attendees with fragrance allergies. Continuing Education Credits Category I Continuing Medical Education credits for physicians, Continuing Education Units for Ph.Ds and nurses, and American Industrial Hygiene Association points for hygienists are pending. Pre Conference Programs Saturday, June 3, 1995 8:30 am - 4:30 pm. Workshop on Risk Communication and Public Involvement. First day of a two-day workshop given by US Environmental Protection Agency staff. Program was well received when given in San Francisco. Attendance is limited to 25. Cost $200.00. Contact 404-639-0708 for additional information. Sunday, June 4, 1995 8:30 am - 4:30 pm Workshop on Risk Communication and Public Involvement (see above). 2:00 pm - 4:00 pm Workshop: "Focusing on the Unique Challenges and Opportunities in Operating Environmental Health Information Services" sponsored by the National Institute of Environmental health Sciences. Contact Beth Anderson, Program Analyst, Superfund Basic Research and Training Program, NIEHS for more information: 919-541-4481. 2:00 pm - 4:00 pm Discussion: "Cumulative Risk and Human Susceptibility" Contact Dr. Gershon Bergeisen, Health Science Advisor to the Director of the Superfund Program, US Environmental Protection Agency, for more information: 703- 603-8816. Databases A room with computers connected to the Internet and with CD-Rom readers will be available at the Congress from 1 - 6 pm on Monday, June 5. This room will be open on Tuesday and Wednesday, June 6 and 7 from 8 am - 6 pm. Congress participants can access the Internet and WWW for a hands-on experience in searching, retrieving, and downloading information. A variety of data bases will be demonstrated such as CLU-IN, VISITT, BFSS, ATTIC, ETRS, OLS, EFIN, DWIE, DRIPSS, HazDat, EMTIC, HMIX, and OAQPS TTN. Knowledgeable staff will be available to answer questions and to provide assistance to Congress participants. Refreshments In keeping with Federal policy, all refreshments, snacks, and meals (except the Monday evening social with cash bar sponsored by the Division of Environmental and Occupational Health of Emory University School of Public Health) will be on a cash basis. Social Monday evening, June 5, 1995 - Poster Session and Reception 6:00 - 8:00 pm Tuesday evening, June 6, 1995 - Country Line Dance Social, 8:00- 10:00 pm. (bring your boots!) Wednesday evening, June 7, 1995 - on your own Points of Interest Martin Luther King Jr. Center The Capitol Stone Mountain Park and Laser Show Atlanta History Center Jimmy Carter Library and Museum High Museum Atlanta Botanical Gardens Atlanta Cyclorama Fernbank Science Center World of Coca-Cola Underground Atlanta SciTrek Atlanta Heritage Row Museum Atlanta Zoo African-American Panoramic Museum CNN Center Wren's Nest Herndon House * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * International Congress on Hazardous Waste: * * Impact on Human and Ecological Health * * * * CONFERENCE REGISTRATION FORM * * (Please type or print clearly) * * * * Name: (Dr./Ms./Mrs./Mr.)_____________________________________________ * * (to appear on name badge) * * * * Position/Tile: ______________________________________________________ * * * * Organization: _______________________________________________________ * * (to appear on name badge) * * * * Mailing Address: ____________________________________________________ * * * * _____________________________________________________________________ * * * * Street Address: _____________________________________________________ * * * * City: _______________________________ State: _______ Zip:___________ * * * * Country: ____________________________________________________________ * * * * Telephone: (_______)___________________________________________________ * * * * E-Mail Address: ______________________________________________________ * * * * Registration Fees: * * * * Early Registration - $150 On-Site Registration - $200 * * * * Full-Time Matriculating Students: * * * * Early Registration - $50 On-Site Registration - $100 * * * * For early registration, please mail this form with your check for $150 * * ($50 for students) to arrive by May 15, 1995, and payable to: * * * * Emory University School of Public Health * * Division of Environmental and Occupational Health * * International Congress on Hazardous Waste * * 1599 Clifton Road, N.E. * * Atlanta, Georgia 30329 * * Attention: Dr. Howard Frumkin * * Telephone: (404) 727-3697 * * Fax: (404) 727-8744 * * * * Cancellation Policy * * * * * All cancellations must be made in writing and mailed or faxed to * * Emory University School of Public Health. A full refund will be given * * if written notice is received by May 30, 1995. A $50 administrative * * fee will be deducted from any refund request received after the cancel- * * lation date. * * * * ( ) REQUEST FOR SPECIAL ASSISTANCE: If you are disabled or have a * * condition that requires either special assistance or * * accommodations, please check at left. We will call you to * * discuss your specific needs. * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * International Congress on Hazardous Waste: Impact on Human and Ecological Health Tentative Program Sunday, June 4, 1995 6:00 pm - 9:00 pm Registration Monday, June 5, 1995 7:00 am - 5:00 pm Registration 8:00 am - 8:30 am Opening Session Welcome. D. Satcher, Centers for Disease Control and Prevention and Agency for Toxic Substances and Disease Registry Charge to the Congress. K. Olden, National Institute of Environmental Health Sciences 8:30 am - 10:00 am Plenary Session Hazardous Waste: State of the Environment. E. Laws, U.S. Environmental Protection Agency Hazardous Waste: Biomarkers and Ecological Health Effects. S. Anderson, Lawrence Berkeley Laboratory 10:00 am - 10:30 am Break 10:30 am - noon Plenary Session Hazardous Waste: Human Health Effects. B Johnson, Agency for Toxic Substances and Disease Registry Environmental Contamination and Health Effects: What is the Evidence? L. Sever, Battelle Pacific Northwest Laboratories noon - 1:30 pm Lunch (on your own) 1:30 pm - 3:00 pm Concurrent Breakout Sessions Session 1 - (Health Effects Track) Health Effects of Incinerators and Other Airborne Exposures Residential Health Impact of Large-Scale On-Site Incineration of Dioxin-Like Compounds. M. F. Cranmer, Cranmer and Associates, Inc. Cardiac and Respiratory Symptoms Associated with Exposure to the Incineration of Hazardous Waste. C. A. Hornung, University of South Carolina The Fort Hall Air Emissions Study. S. W. Metcalf, Agency for Toxic Substances and Disease Registry Neurological Alterations in Children Exposed to Arsenic Lead and Cadmium in San Luis Potosi, Mexico. M. E. Cebrian, Instituto Politecnico Nacionale Session 2 - (Health Effects Track) Health Studies Near Hazardous Waste Sites Health Outcomes Among Residents Living Adjacent to a Hazardous Waste Site. M. S. Miller, Agency for Toxic Substances and Disease Registry Health Risks Among Residents Living Near a Superfund Site - Tucson, Arizona. R. A. Rao, Agency for Toxic Substances and Disease Registry A Health Assessment of Three Communities Near Oxidation Lagoon, in the State of Mexico. M. A. Karam, Public Health Research Center End Stage Renal Disease and Exposure to Hazardous Waste. H. I. Hall, Agency for Toxic Substances and Disease Registry Session 3 - (Ecology Track) Use of Wildlife to Evaluate Transport and Exposure Lead Levels in Exposed Herring Gulls: Differences in the Field and Laboratory. J. Burger, Rutgers University Non-lethal Methods of Assessing Wildlife Exposure to Contaminants. G. P. Cobb, Clemson University Integrated Laboratory and Field Studies of Contaminant Exposure in Badgers (Taxidea taxus) Inhabiting the Rocky Mountain Arsenal. D. J. Hoff, U.S. Fish and Wildlife Service Trans-boundary Movement of Metals from Benthic Sediments into Terrestrial Small Mammals at Hazardous Waste Sites. T. W. La Pointe, Agency for Toxic Substances and Disease Registry Session 4 - (Exposure Assessment Track) Demographic Analysis of Susceptible Populations Using Geographic Information Systems to Estimate Populations. J. Heitgerd GIS Studies of Cancer Around NPL Sites. T. E. Aldrich, University of North Carolina Race, Ethnicity, and Poverty Status of Populations Living Near Cement Plants and Commercial Incinerators. L. M. Harris, U.S. Environmental Protection Agency The Role of Demographics in Public Health Assessments at Superfund Sites: A Case Study of Rocky Mountain Arsenal. E. W. Gregory, Jr., Agency for Toxic Substances and Disease Registry Session 5 - (Community Involvement Track) Community Case Studies I When Federal Agencies Come to Town: Communication and Community Involvement -- Learning by Doing in Stratford. A. L. Boissevain, Health Risk Consultants, Inc. A Framework for Involving Communities Living Near Hazardous Waste Sites in Federal Public Health Actions. L. C. Campbell, Agency for Toxic Substances and Disease Registry Getting the Public's Ideas on Public Involvement: A Case Study. K. J. Black, Neptune and Company, Inc. A Wisconsin Comprehensive Approach to Community Involvement. M. R. Young, Wisconsin Division of Health Session 6 - (Biological Markers Track) Biomarkers Use of Endocrine Biomarkers in Risk Assessment. R. L. Dickerson, Clemson University Chromosomal Aberrations in Blood Lymphocytes are the Biomarkers of Human Exposure to Radiation or/and Chemicals. I. I. Suskov, Russian Academy of Sciences Monitoring Methyl Parathion Exposure in Loraine County, Ohio with urinary p-Nitrophenol Measurements. R. H. Hill, Jr., Centers for Disease Control and Prevention Methyl Parathion Contamination of Private Residences: Risk Assessment and Risk Management Approaches. J. Milton Clark Session 7 - (Engineering Track) Remediation Techniques In situ Remediation of Woodtreating Waste Contaminated with Pentachlorophenol (PCP). J. M. Croom, Quantitative Applications, Inc. Biodegradation of Phenanthrene in Soil in the Presence of Nonionic Surfactants. W. J. Maier, University of Minnesota Soil Gas Entry into Below Grade Basements as an Exposure Route to Trichloroethene. C. G. Uchrin, Rutgers University Novel Systems for Promoting the Reductive Dehalogenation of Carbon Tetrachloride. R. G. Arnold, University of Arizona Session 8 - (Risk Assessment Track) Case Studies in Risk Assessment Lead Soil Remediation: The Quebec Experience of Specific Site Assessment. P. Levallois, Centre de Sante Publique de Quebec/Universite Laval Factors Affecting Risks from Facilities Burning Hazardous Waste. D. A. Canter, U.S. Environmental Protection Agency Some Approaches to the Classification of Radioactive Wastes. A. N. Varbanets, Ukrainian Scientific Hygienic Centre A Fish Consumption Survey of the Tulalip and Squaxin Island Tribes. K. A. Toy, Tulalip Tribes Session 9 Navigating the Informational Maze: Internet, the World Wide Web, CD-ROMs, and Bulletin Boards Internet and the World-Wide Web. L. M. Perry, Agency for Toxic Substances and Disease Registry Accessing the NIEHS Superfund Basic Research Program's Information Systems. B. Anderson, National Institute of Environmental Health Sciences. B. Anderson TBA What Else Is In the World? G. Alston, Agency for Toxic Substances and Disease Registry 3:00 pm - 3:30 pm Break 3:30 pm - 5:00 pm Concurrent Breakout Sessions Session 10 - (Health Effects Track) Health Outcomes in Children Identification of Risk Factors Associated with Human Exposure to Fluoride. F. Diaz-Barriga, Universidad Autononoma de San Luis Potosi Performance of Cytogenetic Biomarkers on Children Populations Exposed to Environmental Pollutants: A Three Years Longitudinal Study. T. Lakhanisky, Institute of Hygiene and Epidemiology Subclinical Health Effects of Environmental Pesticide Contamination in a Third World Setting: Cholinesterase Depression in Children. R. McConnell, Pan American Center for Human Ecology and Health Using Patterns of Child Growth and Development to Assess Community-wide Effects of Low-Level Exposure to Toxic Materials. L. M. Schell, University of Albany, State University of New York Session 11 - (Health Effects Track) Abnormal Immune Findings in ATSDR Studies Overview of the Agency for Toxic Substances and Disease Registry's Multisite Database. M. A. McGeehin, Agency for Toxic Substances and Disease Registry Adoption of an Immune Function Test Battery for Environmental Health Studies. R. W. Amler, Agency for Toxic Substances and Disease Registry Detection of Chronic Lymphocytic Leukemia-Like Monoclonal B- cell Proliferation in Peripheral Blood Samples from Environmental Health Studies. R. F. Vogt, Jr., Centers for Disease Control and Prevention Public Health Implications of Abnormal Immune Findings in ATSDR's Multisite Database. J. A. Lybarger, Agency for Toxic Substances and Disease Registry Session 12 - (Ecology Track) Bioaccumulation and Fate in Ecological Systems The Bioaccumulation of PAHs, PCBs and PCDFs from Sediments by Chironomus Tentans Larvae in the Laboratory and Caged Carp in the Field. P. W. O'Keefe, New York State Department of Health Toxicity and Bioaccumulation of a Mixture of Heavy Metals in Chironomus tentans (Diptera: Chironomidae in Sediment. E. A. Harrahy, Colorado State University Biological Control of the Flux of Heavy Metals from Contaminated Marine Sediments. T. E. Ford, Harvard School of Public Health Accumulation of Copper, Lead and Cadmium in Snail Intermediate Hosts of Schistosomiasis and Fascioliasis in Southwest Nigeria. C. O. Adewunmi, University of Hamburg Session 13 - (Exposure Assessment Track) Exposure Assessment Use of Molecular Similarity in the Assessment of Toxicity of Chemicals. S. C. Basak, University of Minnesota Groundwater and Contaminant Modeling for Exposure Assessment. J. A. Mundell, ATEC Associates, Inc. Using Measured Contaminant Concentrations Versus Modeling Results for CERCLA-Related Air Pathway Risk Assessments. S. A. Smith, Radian Corporation A Case Study in Evaluating Radiation and Chemical Exposures: Hunters Point Annex. J. Davis, Agency for Toxic Substances and Disease Registry Session 14 - (Community Involvement Track) Community Case Studies II Community Involvement in Public Health Investigations: Improved Response and Data Collection Using Neighborhood Volunteers in a South Texas City. B. G. Brown, Texas Department of Health Community as Partners: A Case Study: Partnering Federal and Local Health Agencies with Community Members to Plan, Implement, and Evaluate a Health Education Program. D. Middleton, Agency for Toxic Substances and Disease Registry The Process of Community Involvement - A Case Study: The Bartlesville, Oklahoma Lead Project. M. J. Elder, Oklahoma Department of Environmental Quality Local Health Department Activity at Hazardous Waste Sites: A Spectrum of Responses. H. M. Klein, National Associate of County and City Health Officials Session 15 - (Biological Markers Track) XRF in the Assessment of Lead Exposure Clinical Research Results Using L-Line-X-Ray Fluorescence (LXRF) in Lead (Pb) Exposed and Non-Pb-Exposed Children, Teenagers and Adults. J. F. Rosen, Montefiore Medical Center Body Burden of Lead in a Cohort of Women Formerly Employed at a Lead Smelter. C. V. Lee, Agency for Toxic Substances and Disease Registry X-Ray Fluorescence Results in Bunker Hill Residents Exposed to Lead and a Sample from the General Population. L. D. Stokes, Agency for Toxic Substances and Disease Registry TBA Session 16 - (Engineering Track) Remediation Approaches A Structured Approach to Remediation. G. F. Vajda, Dames & Moore, Inc. Expedited Site Characterization by a Dynamic Process that Employs Field Analytics. A. Henderson-Kinney, Tufts University Resource Allocation Modeling in Environmental Monitoring Design. R. Kuchibhatla, ManTech Environmental Technology, Inc. Costs and Benefits of the RCRA Corrective Action Program: A National Perspective. B. Johnson, U.S. Environmental Protection Agency Session 17 - (Risk Assessment Track) Strategies for Risk Assessment Comparative Risk Analysis: A Panacea or Risky Business? V. Molak, GAIA Unlimited, Inc. A Survey of Perceptions of Environmental Risks: A Comparative Risk Approach at the Local Level. V. R. Nathan, Wayne State University Health Hazards of Hazardous Waste Sites Identified Through Petitions for Public Health Assessments. J. A. Steward, Agency for Toxic Substances and Disease Registry Health-based Contaminant Screening Levels. D. M. Abouelnasr, Agency for Toxic Substances and Disease Registry Session 18 - Environmental Justice Small Area Analysis Techniques for Environmental Justice in Minority and Disadvantaged Communities. E. A. Taylor, Centers for Disease Control and Prevention Washtenaw County (MI) Environmental Justice Community Outreach Program. R. A. Head, Washtenaw Department of Environment & Infrastructure Services Environmental Justice and an Urban Community: A Unique Approach at a Superfund Site. P. K. Seppi, U.S. Environmental Protection Agency Hazardous Waste Disposal Decisions: Democracy, Justice and NIMBYism. H. Elliott 6:00 pm - 8:00 pm Poster Session and Reception. Tuesday, June 6, 1995 7:00 am - 5:00 pm Registration 8:30 am - 10:00 am Plenary Session Environmental Justice: Strategies for Achieving Health and Sustainable Communities. R. Bullard, Clark Atlanta University Hazardous Waste and Risk Assessment -- Safeguarding Children and Other Sensitive Populations. L. Goldman, Environmental Protection Agency 10:00 am - 10:30 am Break 10:30 am - 12:05 Plenary Session 2 X 2 Tables: A Wolf in Sheep's Clothing. D. Ozonoff, Boston University Update on Hazardous Waste Worker Protection. R. Lemen, National Institute for Occupational Safety and Health Workers and the Hazardous Waste Business. A. A. Coia, Laborer's International Union of North America noon - 1:30 pm Lunch (on your own) 1:30 - 3:00 pm Plenary Session Physician Education. T. Walton, National Medical Association Hazardous Waste and Community Voice: Moving Toward Solutions. R. Cox, Sierra Club 3:00 pm - 3:30 pm Break 3:30 pm - 5:00 pm Concurrent Breakout Session Session 19 - (Health Effects Track) Cancer Brain Cancer and Multiple Hazardous Exposures, Especially EMF. T. E. Aldrich, University of North Carolina Case-Control Study of Lung Cancer Mortality in Four Arizona Smelter Towns. G. M. Marsh, University of Pittsburgh A Study of Cancer Mortality of Louisiana Parishes in Relation to Environmental and Occupational Factors. A. E. Gomaa, Agency for Toxic Substances and Disease Registry Pancreatic Cancer Mortality and Railroad Refueling Facilities in Montana. S. R. Prausnitz, Agency for Toxic Substances and Disease Registry Session 20 - (Health Effects Track) Adverse Reproductive Outcomes Birth Defects, Fetal Loss and Developmental Disorders in an Eleven Year Study of an Herbicide Manufacturing Facility with Dioxin Contamination. M. A. Brewster, Arkansas Children's Hospital A Community-based Study of Adverse Pregnancy Outcomes Near a Large Hazardous Waste Landfill in California. M. Kharrazi, California Department of Health Services Maternal Residential Exposure to Hazardous Waste Sites and the Risk of Central Nervous System and Musculoskeletal Birth Defects. E. G. Marshall, New York State Department of Health The Relationship between Birth Defects and Oral Exposure to Trichloroethylene-Contaminated Water in Woburn, Massachusetts. D. Schendel, Centers for Disease Control and Prevention Session 21 - (Ecology Track) Modeling to Assess Ecological and Human Risk Assessing Human Exposure to Air and Soil Contaminant through Homegrown Foods: Defining the Significant Factors. T. E. McKone, University of California Uncertainty in the Use of Plant Uptake factors in Exposure Assessments for Wildlife. K. M. Morgan, Oak Ridge National Laboratory An Assessment of Exposure from Anthropogenic Mercury Emissions in the U.S. G. Rice, US Environmental Protection Agency Integrated Assessment of Ecological and Human Health Risk of Mercury Exposure. R. Schoeny, US Environmental Protection Agency Session 22 - (Exposure Assessment Track) General Exposure Effect of Variability in Estimated Half-Lives of PCBs in Humans on Exposure Assessment. J. C. Kissel, University of Washington Redefinition of Abnormal Susceptibility to Environmental Chemicals. W. E. Morton, Oregon Health Sciences University Use of Data Gap Sampling and Analysis Plans to Prepare US Air Force Installations for ATSDR Public Health Assessments. J. R. Wireman, US Air Force Human Exposure to Methyl Parathion in Private Residences, Ohio. E. Esteban, Centers for Disease Control and Prevention Session 23 - (Community Involvement Track) Community Case Studies III Organization Industrial Waste in Samarita, Sao Vicente City, SP, Brazil. A. Soares, Sec Higiene E. Saude de Santos Dumping on a Community: A Tale of Waste. M. B. Harwitz, Munisport Dump Coalition, Inc. Public Input and Involvement in the Selection of Exposure and Health Outcome Studies: A Case Study of Jacksonville, Arkansas. M. F. Cranmer, Cranmer and Associates, Inc. The Use of Wildlife Toxicology in Ecological Risk Assessment of Hazardous Waste Sites: Assessment, Litigation, and Remediation. R. J. Kendall, Clemson University Session 24 - (Toxicology Track) - Toxicology Guidelines for Assessing Adverse Health Effects. M. D. Williams, Agency for Toxic Substances and Disease Registry The Health Effects of Chronic Oral Exposure to Polychlorinated Biphenyls. O. M. Faroon, Agency for Toxic Substances and Disease Registry Rapid Assessment of Chemical Contamination and Determination of Toxicity Equivalents at a Hazardous Waste Site. W. E. Mashburn, Clemson University Studies on the Toxic Impact of Hazardous Waste: Organophosphate Insecticide Induced Impairment in Catecholaminergic system of Developing Brain and Heart in a Mammalian Model. Dr. Nayeemunnisa, Bangalore University Session 25 - (Engineering Track) Engineering Approaches Based on Risk Assessment Risk Assessment and Remediation at the Seymour Superfund Site: A Case Study. S. T. Atwood, Geraghty & Miller, Inc. The Georgia Hazardous Site Response Program: Using a Risk Based Approach to Determine Clean-up Levels in Soils and Groundwater. K. L. Mitchell, Georgia Department of Natural Resources Construction Within a Contaminated Area: When is it Feasible? L. M. Smith, Law Engineering & Environmental Services, Inc. The Use of Natural Mineral Sorbents in Medicine, Agriculture and Ecology. K. M. Sinyak, Universitat Hamburg Session 26 - International Environmental Health Activities on the Texas-Mexico Border. R. J. Dutton, Texas Department of Health Regional Agreements on the Transboundary Movement of Hazardous Waste: Efforts Toward Sustainable Development. C. Warrick, Agency for Toxic Substances and Disease Registry The Silent Trade of Hazardous Wastes into Lebanon: A Case Study. M. Jurdi, American University of Beirut Contaminations of Environment and Public Health: Arguments for International Collaboration. L. T. Shevchuk, Lviv State University Session 27 - (Risk Communication and Education Track) Community I A Model for Medical Education for Widely Dispersed Physicians. A. P. Janssen, Agency for Toxic Substances and Disease Registry Developing Successful Environmental Physician Education: Lessons Learned. R. R. Tardif, Oak Ridge Institute for Science and Education Strategies for the Prevention of Mercury Exposition among Adolescents from Gold Mining Areas. V. de M. Camara, Federal University of Rio de Janeiro Community-Based Strategies for Communicating Environmental health Risks: A Case Study of the Chattanooga Creek Site. T. Tinker, Agency for Toxic Substances and Disease Registry Wednesday, June 7, 1995 7:00 am - 5:00 pm Registration 8:30 am - 10:00 am Plenary Session Environmental Contaminants as Endocrine Disrupters. L. Gillette, University of Florida Environmental Estrogens: Is There a Human Health Problem? S. Safe, Texas A & M University 10:00 am - 10:30 am Break 10:30 am - 12:05 pm Plenary Session Indigenous People. T. Goldtooth, Indigenous People Environmental Network Cleaning It Up. P. Seligman, Department of Energy Ecogenetics: From Ecology to Health. D. Nebert, University of Cincinnati 12:05 pm - 1:30 pm Lunch (on your own) 1:30 pm - 3:00 pm Concurrent Breakout Session Session 28 - (Health Effects Track) Neurobehavioral Outcomes Subject Factors Affecting Performance on ATSDR's Adult Environmental Neurobehavioral Test Battery (AENTB). W. K. Anger, Oregon Health Science University Chronic Neurotoxicity as a Result of Landfill Exposure in Port Orchard, Washington. A. R. Hirsch, Smell & Taste Treatment and Research Foundation Toxic Encephalopathy: Evaluation by Neuroselective Cephalic Transcutaneous Electrical Nerve Stimulation and Comparison with other Tests. J. J. Katims, Neurotron, Inc. Psychologic Concerns of Communities Near Hazardous Waste Sites. P. G. Tucker, Agency for Toxic Substances and Disease Registry Session 29 - (Health Effects Track) Lead Exposure in Children A Case-Control Study to Determine Risk Factors for Elevated Blood Lead Levels in Children: The Idaho Silver Valley. M. M. Nogueras, Agency for Toxic Substances and Disease Registry Use of Stable Lead Isotope Systematics to Identify and Apportion Sources of Environmental Lead in Residential House Dust. P. J. Ashley, Maryland Department of the Environment Measuring Lead on Hands for Assessing and Preventing Childhood Exposure. H. W. Mielke, Xavier University of Louisiana Environmental Lead Exposure and Blood Lead Levels among Children of Mexico City. I. Romieu, Instituto Nacional De Salud Publica Session 30 - (Ecology Track) Ecological Assessments Preliminary Ecological Risk Assessment at a National Priorities List Site in South Carolina. G. P. Cobb, Clemson University Biomarkers in Endemic, Enhanced and Enclosed Wildlife: Their Use in Contaminant Bioavailability Assessments. M. J. Hooper, Clemson University Biochemical Assessment of Cyanide-induced Toxicity in Migratory Birds from Gold Mining Hazardous Waste Ponds. C. A. Pritsos, University of Nevada A Model Insect as a Biomarker of Mercury Toxicity in Mammals. S. Ahmad, University of Nevada Session 31 - (Exposure Assessment Track) - Air Exposure The Use of Breath Samples as the Indicator of Internal Dose after Tetrachloroethylene Exposure. C. P. Weisel, Rutgers University & UMDNJ-Robert Woods Johnson Medical School Exposure Assessment for Toxic Air Pollutants from Hazardous Waste Incineration: The Vertac/Hercules Superfund Site. L.-J. S. Liu, University of South Carolina Evaluation of Potential Exposure to Nearby Residents from the Operation of a Hazardous Waste Incinerator at the Vertac/Hercules Superfund Site. M. F. Cranmer, Cranmer and Associates, Inc. The Lower Rio Grande Valley Environmental Monitoring Study: Applying Human Exposure Science to Public Health Concerns. M. Schwab, ManTech Environmental Technology, Inc. Session 32 - (Workers Track) - Worker Exposure to Heavy Metals Exposure Assessment for Heavy Metals in Oruro, Bolivia, 1994. S. H. Wainwright, Centers for Disease Control and Prevention Exposure of Workers in Recycling of Hazardous Lead Batteries' Wastes in India. J. M. Dave, Jawaharalal Nehru University Effects of Automobile Wastes on the Health of Roadside Mechanics. M. K. C. Sridhar, University of Ibadan Use of Historical Data in a Contemporary Public Health Assessment of a Uranium Mill. K. Silver, Boston University Session 33 - (Toxicology Track) - Toxicology of Chemical Mixtures Effect of Vitamin & Mineral Intake on Toxicity of Complex Mixture (Arsenic, Benzene, Cadmium, Lead and Trichloroethylene). B. W. Kemppainen, Auburn University The Mechanism of Polychlorinated Biphenyl (PCB)-Neurotoxicity. B. Jahan-Parwar, State University of New York Effect of Ozonation on the Epigenetic Toxicity of Polycyclic Aromatic Hydrocarbons. S. J. Masten, Michigan State University Toxicity Assessment of Inorganic Chemical Mixtures Found at Hazardous Waste Sites. M. M. Mumtaz, Agency for Toxic Substances and Disease Registry Session 34 - (Policy Track) Community Policy Confronting Superfund Mythology: The Case of Risk Assessment and Management. K. D. Walker, Harvard University Locking in Environmental Risk: A Model Environmental and Health Baseline Ordinance. B. S. Ruhl, Legal Environmental Assistance Foundation, Inc. Building Neighborhood Based Programs for Site Remediation and Redevelopment. J. A. Shaw, New Jersey Department of Environmental Protection Small Communities of Argentina React to the Transfer of Hazardous Wastes Technologies. M. N. Epelman, Environmental Commission, City Council of Buenos Aires Session 35 - (Risk Assessment Track) - Methods and Guidelines for Health Risk Assessment - Session I An Approach to Exposure Analysis that Identifies the Types of Data and Data Groups Associated with Remedial Investigations, and Then Identifies Ways to Reduce Uncertainties. P. J. Lioy, Environmental and Occupational Health Sciences Institute Risk Assessment of Dioxin Congeners via Plant Uptake. B. H. Magee, Ogden Environmental & Energy Services Risk Assessment and Management for Highly Toxic Air and Water Emissions and solid Wastes: A Case Study. S. Dhara, Children's Science Congress The Relationship Between Site Characteristics and Reported Health Conditions. D. Abouelnasr, Agency for Toxic Substances and Disease Registry Session 36 - (Risk Communication and Education Track) - Community II Communication and Negotiation at Hazardous Waste Sites: Some Psychological and Sociological Influences on Scientific Debate. H. Tosteson, Agency for Toxic Substances and Disease Registry Why Aren't You Listening? The Need for an Environmental Needs Assessment Survey. H. H. Lenz, Oregon State University The Spirit of our Times: Forging the Way to a Better Understanding of Public Health Concerns at Federal Facility Sites. V. H. Sublet, University of Cincinnati Citizen Participation and Empowerment in the Context of Local Environmental Hazards. R. C. Rich, Virginia Tech 3:00 pm - 3:30 pm Break 3:30 pm - 5:00 pm Concurrent Breakout Session Session 37 - (Health Effects Track) - Health Studies Following Hazardous Waste Exposures Environmental Contamination by Hexachlorocyclohexane in a Large Area in Rio de Janeiro - Brazil. A. M. C. B. Braga, Oswaldo Cruz Foundation Airborne Cyanide Pollution. T. R. Oesch, Martin Marietta Energy Systems Cancer Risks in an Arsenic Contaminated Area of Chile. M. I. Rivara Z, Chile Ministry of Health Mortality Study of Children Residing Near ASARCO Copper Smelter in Ruston, Washington: Cohort construction and Follow-up. F. Westrum, Washington State Department of Health Session 38 - (Health Effects Track) - Epidemiology and Hazardous Waste Combining Qualitative and Quantitative Approaches to Assessing Hazardous Waste Impacts on Human Health and Well-Being in Local Community Studies. D. C. Cole, McMaster University Risk Factors of Hazardous Substance Releases Resulting in Personal Injuries and Evacuations. H. I. Hall, Agency for Toxic Substances and Disease Registry Environment-Related Cancer Surveillance. Y. Mao, Health Canada The Relationship Of The Level and Length of Mixed Chemical Exposures To Reporting Rates of Adverse Health Outcomes: A Multisite Approach. J. R. Burg, Agency for Toxic Substances and Disease Registry Session 39 - (Ecology Track) - Ecology and Human Exposure Risk Characterization of Methylmercury Effects on Human Populations and Wildlife Species: Fish Mercury Content and Fish Consumption as Contributors to Uncertainty and Variability. K. R. Mahaffey, US Environmental Protection Agency Human and Ecological Exposure Pathways via Food-Chain at Air Force Sites. Maj. B. J. Larcom, US Air Force Retention of Ingested Benzo(a)pyrene and Related Aromatic contaminants in Hens, Pigs, and Cows. S.-C. Tsai, Agency for Toxic Substances and Disease Registry TBA Session 40 - (Exposure Assessment Track) - Exposures at Smelters and Incinerators Lead Exposure in Children Living Near a Smelter Complex in the USA-Mexican Border. F. Diaz-Barriga, Universidad Autononoma de San Luis Potosi Quantifying Individual-level Lifetime Residential Exposure to SO2 in Four Arizona Copper Smelter Communities: Statistical Issues. R. A. Stone, University of Pittsburgh Quantifying Individual Residential Exposure to Smelter Emissions in Four Arizona Copper Smelter Communities: Exposure Estimation Procedures and Results. N. A. Esmen, Esmen Research and Engineering Exposure Assessment at a Former Mining Site: The Kansas Experience. R. Dhara, Agency for Toxic Substances and Disease Registry Session 41 - (Workers Track) - Worker Exposures Neurotoxicity as a Result of Acute Nitrogen Tetraoxide Exposure. A. R. Hirsch, Smell & Taste Treatment and Research Foundation Assessment of Toxic Exposures in Waste Incineration. S. K. Hall, William Paterson College Exposure Assessment of Workers at Hazardous Waste Sites Based on Concurrent Environmental Monitoring and Breath Sampling. C. J. Komis, US Department of Labor The Cleanup of Clandestine Drug Laboratories: A Planning and Program Implementation Guide. R. P. Hill, Centers for Disease Control and Prevention Session 42 - Laboratory New, Fast, Ultra-sensitive Analytical Methods for Assessing Human Exposure to Environmental Toxicants. D. G. Patterson, Jr., Centers for Disease Control and Prevention Quantification of Non-persistent Pesticides by Isotope Dilution-High Resolution Mass Spectrometry. J. Barr, Centers for Disease Control and Prevention Measurement of Radionuclides in Human Biological Specimens. W. Ting, Centers for Disease Control and Prevention Biological Monitoring of methyl tert-Butyl Ether in Controlled Chamber Experiments and Site Investigations. D. L. Ashley, Centers for Disease Control and Prevention Session 43 - Policy Who Sets the Environmental Agenda? D. B. Sachsman, University of Tennessee at Chattanooga Science Put to Service: Enhancing Environmental Health Services in Communities Affected by Hazardous Substances. M. Y. Lichtveld, Agency for Toxic Substances and Disease Registry Incidents of Large Scale Lead Poisoning in East Trinidad: A Dire Need for Sustainable Practices in Hazardous Waste Disposal. I. Chang-Yen, University of the West Indies Uncertainty and Causation in the Law: Towards a Common Practice do Deal with Risks. P. F. Ricci, Ricci and Molton Session 44 - (Risk Assessment Track) - Methods and Guidelines for Health Risk Assessment - Session II A New Approach for the Study of Hazardous Waste Sites in Mexico. F. Diaz-Barriga, Universidad Autononoma de San Luis Potosi A Multi-Plant, Multi-Pathway Risk Screening of Waste Kiln-Dust Management at U.S. Portland Cement Plants. F. A. Smith, US Environmental Protection Agency Exposure Guidelines Based on Total Recipient Dose and Not Proposed Air Levels. A. Winnert, Environmental & Toxicology International, Inc. A Risk-based Approach for Setting Site Evaluation Priorities in Former Gazwork Sites in France: A National Survey. D. Zmirou, Grenoble University Medical School Session 45 - (Risk Communication and Education Track) - Community III Above and Beyond Basic Public Participation. L. P. Mathai, Neptune and Company, Inc. A Newsletter "Health and Waste Network." M. Hours, Universite C. Bernard Lyon I. To Clean the Environment, Catch Them Young: The 1994 Children's Science Congress Experience. S. Dhara, Children's Science Congress Thursday, June 8, 1995 7:00 am - noon Registration 8:30 am - 10:00 am Plenary Session Limitations of Clinical Laboratory Data for Environmental Health Diagnosis. H. Kipen, UMDNJ-Robert Wood Johnson Medical School Innovative Technologies for Site Clean-up. W. Kovalick, Environmental Protection Agency 10:00 am - 1:30 am Break 10:30 am - 11:10 am Plenary Session Hazardous Waste: Impact on Human Health in Europe. H. W. Wyes, World Health Organization 11:15 am - 12:15 Closing Session A. Gilman, Health Canada. 12:15 - 12:45 Wrap-Up J.S. Andrews, Agency for Toxic Substances and Disease Registry H. Frumkin, Emory University 12:45 Adjourn ------------------------------------------------------------------------ [Image] ATSDR Home Page ------------------------------------------------------------------------ Charlie Xintaras / [log in to unmask] <<<<<< Attached TEXT file named "mutant gene" follows >>>>>> A novel cytochrome P-450IID6 mutant gene associated with Parkinson's disease. Tsuneoka Y; Matsuo Y; Iwahashi K; Takeuchi H; Ichikawa Y Department of Biochemistry, Kagawa Medical School. J Biochem (Tokyo) 114: 263-6 (1993) Abstract Genetic polymorphism of the CYP2D6 gene [phenotypically individuals are either poor metabolizers (PM) or extensive metabolizers (EM)] has been reported to be associated with susceptibility to Parkinson's disease. We analyzed CYP2D6 genes from Japanese patients and controls, and found that EM/PM polymorphism is not a suitable marker for populations with a low PM frequency. However, a novel mutant highly associated with Parkinson's disease was discovered. The mutation was located at the HhaI site in exon 6 and changed a conserved amino acid residue, Arg296, to Cys296. The risk factor for the mutant homozygote was 5.56 (95% CI, 1.30-23.82). These results suggest that the HhaI polymorphism in the CYP2D6 gene is a part of the molecular basis of Parkinson's disease. Mesh Headings Arginine Base Sequence Cysteine Cytochrome P-450* Deoxyribonucleases, Type II Site-Specific Genotype Homozygote Human Hydroxylases* Japan Molecular Sequence Data Mutation Parkinson Disease* Polymerase Chain Reaction Restriction Fragment Length Polymorphisms Unique Identifier: 94086475 Gene Symbols CYP2D6 Chemical Identifiers (Names) EC 1.14. (Hydroxylases) EC 1.14.99.- (debrisoquine 4-hydroxylase) EC 3.1.21.- (endodeoxyribonuclease HhaI) EC 3.1.21.4 (Deoxyribonucleases, Type II Site-Specific) 4371-52-2 (Cysteine) 7004-12-8 (Arginine) 9035-51-2 (Cytochrome P-450) <<<<<< Attached TEXT file named "platelet mtDNA" follows >>>>>> PCR analysis of platelet mtDNA: lack of specific changes in Parkinson's disease. Sandy MS; Langston JW; Smith MT; Di Monte DA California Parkinson's Foundation, San Jose 95128. Mov Disord 8: 74-82 (1993) Abstract An alteration within the mitochondrial DNA (mtDNA) has been hypothesized to underlie the deficiencies in mitochondrial complex I activity observed in the platelets, striatal muscle, and brain tissue of individuals with Parkinson's disease. Here we utilized the polymerase chain reaction (PCR) to analyze mtDNA obtained from the platelets of nonmedicated patients with early Parkinson's disease (n = 8) and aged-matched controls (n = 6) for the presence of deletion(s) or addition(s) equal to or greater than 50-100 base pairs. Initial attention was focused upon detecting a 4.977 kb deletion previously found in the brains of parkinsonian patients and some aged controls. Indeed, a large deletion of approximately 5.0 kb was observed in the platelet mtDNA from all parkinsonian individuals. However, this defect was also found in all age-matched controls as well as in a group of young healthy subjects (n = 5). In addition, we searched for the presence of smaller changes in platelet mtDNA from parkinsonian patients by PCR analysis of four mtDNA segments that code for seven of the complex I polypeptides. No large deletions or additions were detected within these four regions of mtDNA in any of the disease or age-matched control samples. We conclude that (a) a 4.977 kb deletion is apparently present in a subpopulation of platelet mtDNA from all individuals, and (b) no macrosequence alteration in mtDNA is likely to underlie the deficiency in complex I activity reported in platelet mitochondria from parkinsonian patients. Mesh Headings Adult Aged Base Sequence Blood Platelets* Chromosome Deletion DNA, Mitochondrial* Gene Amplification Human Male Middle Age NAD(P)H Dehydrogenase (Quinone) Parkinson Disease* Polymerase Chain Reaction* Support, Non-U.S. Gov't Unique Identifier: 93125606 Chemical Identifiers (Names) EC 1.6.99.2 (NAD(P)H Dehydrogenase (Quinone)) (DNA, Mitochondrial)