Wendy, I have always thought there was something about personality or at least development involved, but I have nothing to prove it.I know this: the dopamine pathways of the brain go through critical developmental periods right after birth, and again at the end of the second year of life continuing into the next two-four years. When this is occuring, the synapses are rapidly forming and connecting up the sympathetic nervous system. In the first year psychologically the developmental job is to internalize regulation of affects in the soothing,-stimulating interaction with the mother. In the second year the job is for the child to learn to beginnings of inihbition, and impusle control. If these psychological developments are encoded in the neurons at critical dopamine developmental times along with parts of the control of the body, it seems reasonable to assume they connect up. The nigro-striatal part of the dopamine pathway is critical in the second year. One final note is that I have informally polled a number of early onset PD patients admittedly not a very large sample. Allmost without exception--maybe one or two out of about 8 or 10, had something strange in the first year--illness or nutritional deficiencies. I'm hoping to do some more formal research. The last thing is that because of this I firmly believe that with motivation, concentration, and focus, we can relearn--i.e. retrain our body memory in many of the functions that we have lost. It takes a little time and effort but It can happen. What is important is to fight that deadly passivity, and really keep the mind going all the time. I force myself to engage in new kinds of learning all the time--especially right brain type stuff. While I'm on line to you I want to thank you for your great postings-=-interpsyche forum, medline articles, etc. It's a great service. Claudia Elliott , Chicago, Ill.