Hi, I think i've evolvede a fairly original way of taking my PD medication (Sinemet 25/100), and I would like your comments and reactions. My doctor prescribed my meds be taken 4 times daily, after breakfast, lunch, supper and before bed. I have found that I am best off taking my meds on an as needed basis. This means that if my job requires that I sit for a few hours and type, I don't need medication. But if I am active, walking around, giving a talk, etc. I take my medication about an hour before the busy period.My main symptoms, after 8 years of PD, are a marked tremor in one hand, a stumbling walk, and voice problems. So if I'm going tothe movies or theatre for a few hours it makes no sense to take the medication. But if i'm going togive a one hour talk I need my symptoms to be reduced by the Sinemet. So far my "as needed" approach seems to be working out. This also means that on many days i need less Sinemet, Sometimes I get throiugh a day with only 2 pills or 3. I would likemyfellow pPD friends to give me their reaction and let me know if you have ever tried this approach. haasa@ [log in to unmask]