Hi Adelaide, I take my meds. the same way. I break up my Sinemet 25/100 into six crumbs every morning and take them about every 3 hours. I find that this way gives me the most even kind of response. When I feel myself starting to get slow I take a dose of Sinemet and a Permax. Doctors don't always like us to do that, because they're not sure we won't err too much on the side of dyskenesia. I had to change doctors to get one to cooperate. Claudia