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Hi, In response to the nausea that you get when you take the Sinemet. I to found that when I took the sinemet that I became nausea's. This seemed to happen more if I took it with meals or right after a meal. I started taking it from 30 to 60 minutes before or after I ate and that helped. I also found that if I had a very high protein meal or if I ate a lot or sugars and caffiene products that the sinemet would not work as well. I hope you find this helpful for you. I have found that each person has to judge what works for them and then go from there. Dar Newman [log in to unmask]