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Thank you Dick! That's what I call a USEFUL contribution. John On Tue, 9 May 1995 [log in to unmask] wrote: > Dick Metzler: Dietary proteins of all kinds interfere with the proper > absorbtion of Sinemet (levadopa) but some are worse than others. In my case > all dairy products are the worst - followed by meat, fish, poultry, egg > whites, legumes, cereal. A vegetarian diet is my best bet but hard to stick > to. Interestingly shellfish and crustachians don't bother me. Milk and ice > cream do me in for hours and it is getting to the point where enjoying dairy > foods isn't worth the discomfort after. > > Dietary protein molecules are large sized amino acids. Levadopa is also > protein but are small molecules. Here is what happens ---- > > You take a dose of Sinemet and eat some protein food. All these amino acids > are absorbed into the blood stream. At the bus station called Blood Brain > Barrier the large dietary proteins muscle their way onto the bus and fill up > most of the seats. The smaller Sinemet molecules are left standing at the > station whilst dietary proteins go into the brain and muck up the place to > the extent that the little bits of Sinemet that were able to get on the > Blood Brain Barrier bus arn't able to do much good. > > More levadopa gets on the BBBB if you take it on an empty stomach - a half > hour before eating or one hour after eating. > > You can't stop eating dietary protein or you will become malnourished. You > just learn when to eat it and you don't eat as much. Americans eat too much > dietary protein. > > Another little nugget - don't take anti-acids (Tums, Milk of Magnesia, etc) > at the same time you take Sinemet as Sinemet won't work as well if at all. > Wait an hour. > > Take Sinemet with an acid drink like orange juice or lemonade as it dissolves > faster. However, if you are suffering with acid stomach (heartburn), take > Sinemet with water. > > If Sinemet taken on an empty stomach makes you nauseaus you will have to eat > something. One soda cracker and orange juice will help. >