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I am concerned about the amount of sinemet I need to give relief of symptoms of P.D. What do others think. I choose to have as little medication as possible and as few mixtures of tablets to be able to function reasonably. I ve had P.D. 8 years and RLS (I call it restless everything). I began eldepryl 4yrs ago, sinemet 18 months ago with 1 CR at night. Now I am needing sinemet 3/4 hourly, some CR, and some 25/100. Even at night I wake 4 hourly and get no sleep if I go without. This means about 250/1000 carbidopa/levodpa per day. Dr has just recently given me Prozac. 20 mg daily. No adverse reaction and no improvement so far. Can t get Permax here (New Zealand). Reading about free radicals and the fact that only 10-20% of the medication reaches or is used by the brain. Makes me want to find a more efficient way of getting dopamine or coping with P.D. Pam Barnett. Kim Barnett <[log in to unmask]>