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Pat, thank you for elaborating 'standing on shoulders'. I used to do that .. and usually add what we called bicycling - which was pretending one was pedaling. Relating this brought to mind one of my early life experiences; my brother and I had re-worked the bicycle we had gained access to after my father no longer used it (gasoline shortage of WW2), and I made the test ride. Somehow, I lost control avoiding something and ended up upside down in the roadside ditch - still on the heavy bike - suspended by bushes such that I never touched the ground. I recall being delighted at not being injured, but then bothered by my brother's concern being for the condition of the bike rather than me. You did not elaborate (as I did not previously) the whole story of taking medicine during the night. I consider this important, so will rectify my neglecting to complete the commentary. l-dopa/carbidopa seems to need 'stomach time' and then transport to the duodenum. This latter may be lacking unless some bulk is ingested after the pill and liquid. I often use a prune at least. My experience with Sinemet CR is miniscule, but it may also need the transport beyond the stomach to get to the loci where LNAAs are sought by the blood stream. All-bran and a prune seem optimal in my experience - taken ten minutes later if not inconvenient. Any corroboration of these conjectures from 'lurkers' or disagreement arguments and data that contradicts are invited - preferably to the list, but to me only if you choose. Best wishes, Ron <[log in to unmask]> Ronald F. Vetter