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Ron Vetter queried about the adsorbtion data for Sinemet vs Sinemet CR and also mentioned that some folks are grinding CR tablets for delivery thru a gastric tube. The entire principle of a Sinemet CR controlled release tablet is based upon keeping the table intact so it can slowly dissolve in the GI tract with a resultant slow adsorbtion of carbidopa and levodopa. The slow adsorbtion is meant to smoothen and prolong the response to levodopa. Grinding up the CR tablet destroys its purpose. If there is a need for a gorund up preparation of levodopa, and I am sure such needs to arise for certain individuals, then please grind up Sinemet tablets rather than Sinemet CR tablets. Ron Vetter asked abput data on adsprbion characteristics. There are a number of technical publications that go into that. There is also a product monograph that goes into great detail on the adsorbion characteristics of Sinemet CR that is available to pharmacists and physicians through my companies Product Information Center. If anyone wants to receive the product monograph or specific references to published works on adsorbion kinetics, please contact me directly on Email. My account is: [log in to unmask] Also the DuPont Pharma Product Information Center telephone number is 800-474-2762 Best regards to all the participants in this incredible list. Joe Irr