My mother has been on Sinemet for several years. Last year she was started on Permax. She is on a large dose of both. She has not had any improvement since the Permax was started. Her memory is worse and my father has to dress her now and she can only walk a few steps when she is good. Is it better to stop the Permax and start another drug? It seems to me if it has not helped her it should be stopped. I would appreciate any help. Thanks