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I am going to see my neurologist in a months time and having recently joined the list, I am planning to astonish him with my newly acquired knowledge !He will probably throw me out of his consulting room but not before I have had full value for my 100 buck chat which last time was "How,s your father", the vagaries of the weather, the World Cup and "By the way how are you? "Hi Bill, I hope you are not wired up and there lurking otherwise you might cancel my appointment and don't want to motor 75 miles to your nearest competitor." Maybe I should go anonymous although I am not intend to take part in "Summerwind" type exchanges unless improved medication stokes up my libido. Having studied drug therapy with more interest I am now confused about my own prescriptions.I have had diagnosed PD for three years and have been on Selegiline for the past two years at two 5mg tablets a day.As I am self employed I can pace myself but need to be pretty active. I have however been getting slower and was told before Christmas that at my discretion I could go on to Sinemet at three tablets a day of 10/100.and keeping on with the Selegelin because of it's alleged neuroprotective properties.The Sinemet did not seem to make any really worthwhile improvement and so after a time I gave it up as I felt posponing the future side effects was a good thing and if I could be a little more relaxed the need for medication would be reduced.Now although I am having some success on the relaxation front, I think the time is coming when I will have to take medication more seriouslsy and plan to discuss this with old Bill when I see him next month. I am well under 70 and from PD literature and letters on this list it would seem that the minimum amount of Cardidopa needed to make the Levadopa effective is 75mg per day and at three tablets of 10/100 I would appear to only be getting 30mg per day. Furthemore I read in Dr Iacono's recent address on AOL last Friday that hesaid don't have milk or milk products with Sinemet as they block the action.With these two points in mind it does not seem surprising that I have not had any help from Sinemet? unless I am one of those who is Sinemet resistant. Any comments would be highly appreciated. David Langridge