Hello, I recently joined this list and I have some questions I would like to ask the group. My mother is 60 years old and was diagnosed with PD about five years ago. Originally, her neurologist put her on Sinemet 25/100 3 times a day. Her reaction to this drug was positive, but the side affects were not tolerable (she threw up 3-5 times a day). She was then prescribed Sinemet CR and with help of Don-Peridone (a medicine we order from Canada) and Lodysin (a medicine she gets it from her doctor) her nausea was reduced and she was able to tolerate the Sinemet CR. In addition to the Sinemet CR, she was taking about five other drugs to treat her constipation, headaches and other problems. This lasted for about 18 months. However, last summer she started complaining that she was getting some pressure in her chest. She describes it as if she has a ring around her neck and/or a sucking tube inside her chest. Sometimes she describes it as a ball under her sternum (in the middle of her chest). We took her to a gastrologist and did an endoscopy and also checked her heart. The test results were normal, and we have been unsuccessful in relieving her chest pressure. During the last couple months, she noticed that during these chest pressure spasms her speech slows down or slurs and sometimes it is hard to for her to speak at all. In the beginning, it usually happened in the evening, especially if she got very emotional or tired and it would disappear when she went to bed. But recently these spasms started occurring in the afternoons and last from 20 min. up to 2-4 hours. She says that it helps if she goes for a walk. The other problem she has is her headaches. Again, the explanations I am getting are very strange, but my mother describes that she has some air (or air pressure) in her head. She also calls it an elevator effect. Every time we take an elevator together she asks me: "Do you feel it, do you ? That s exactly what I have in my head." I don t really know what to say because I don t feel it. She also says that she gets dizzy if she reads for more than 15 min. or sometimes if she watches TV. She says the dizziness sensation is as if her head were underwater. Her neurologist is a very good doctor, but she can t explain wrong with my mother s chest pressure or help her with her headaches. She referred my mother back to her internist with these problems, but the internist just sent her back to her neurologist. It is clear to me that they do not know what to do. I am posting this e-mail with the hope that somebody on this list might have some experience or ideas on how to control chest pressure and these types of headaches. In addition, my mother is very constipated and only gets relief from enemas. Any suggestions or ideas you might have would be greatly appreciated. Lenny Lozinsky [log in to unmask]