I don't have anything solid/scientific to offer, just a personal observation. I am slightly asthmatic, mostly in the winter when furnaces are blowing dust around. This past winter I noticed that my lungs felt tighter and breathing was harder than usual, I also noticed some pain that seemed to occur at the "edges" of my lungs. The difference between this year and last, this year I was on Permax 4x0.25mg three times a day (also to be complete I was on Eldepryl as well). I cut back on the Permax to 1x0.25mg three times a day and my breathing got easier and the pain around the edges of my lungs went away (and of course I got slower, but it was in the name of personal research). Unfortunately I did this at about the time of the year that the asthma would normally improve anyway, so I can't be sure of the Permax connection. None the less I still suspect the Permax, maybe I'll be able to verify that as I nudge the dosage back up. -- John Stafford [[log in to unmask]]