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My mom contacted my dad's doctor last week but he was out of town. His staff called Monday to advise my folks to discontinue the Eldepyrl. He also saw his regular doctor back home Monday and that doctor also took him off his Maxzide, and advised him to see his neurologist ASAP. My dad has an appointment with his doctor in Oklahoma City on July 5th. According to my mom he had a better day today. Better mood, more energy and could get around with just his cane, didn't need his walker. I think that this improvement is more a easing of anxiety over his situation due to the action and reaction of his doctor's more than any lessening of medicinal effects. I received a response stating that it takes about 3 weeks for the Eldepyrl to get out of his system, so I know for sure that effects from this drug are still very active in his bloodstream. I received several E-mails regarding problems the sender or family member had with Sinemet CR. Apparently many patients have adverse reactions to this drug and must take the "regular" formula to have any success drug wise at all. Why then do doctor's start their patients out on a drug they know that the greatest majority of patients can't take? Why set the patient up for failure if the "regular" formula will work better and is also available in generic thus a finacial savings as well? Any ideas? I really do appreciate all of the kind words, suggestions and overwhelming support I have received. And so do my parents. Most of your notes are printed and sent on to them back home. Virginia Herd [log in to unmask]