My dad 74, diagnosed with PD 8 months ago, has been taking Sinemet CR since diagnosed and has been taking Eldepryl for 2 1/2 months. Since beginning the Eldepryl he has been much more listless, rarely gets out of his chair. His 'dizzy' spells from his Meneire's syndrome are more frequent. He has anxiety attacks which will root him in his chair for 8 hours, no one can get him up out of that chair. He's too scared he'll fall and will go absolutely rigid if we try. He sleeps alot. He'll watch an hour program and miss at least 30 minutes of the show. When he has good days he can slowly fix lunch. He showers without assistance, even does his own laundry, slowly but he gets it done. He has gone from walking 3 to 4 miles a day (just 8 months ago) to barely making it to the car a couple of times a week. He takes 3 Sinemet CR 50/100 each day, and 1 Eldepryl 5mg each day. He also takes Relaphen (arthritis), Maxzide (meneire's) and Lozal [spelling?] (circulation). All of this to ask a question. Is this normal for this disease and this regime of medication? Today was my sons 9 birthday party. My dads ONLY GRANDCHILD and he slept sitting up in a hard straight back chair at the kitchen table through most all of the festivities. Up until 8 months ago this would have NEVER happened. He adores this child and would in times past never miss anything this child ever did. His doctor's first said he had the slow progressing type of PD and that it was in it's very early stages. Could be functional for another 20 - 25 years (his parents lived to be 95 & 96). In April (5 months after diagnoses) they now say he is in the later stages and the next step is a wheel chair, this time next year he will be vegetative. Did his doctors miss his diagnosis? Could his medication or insufficient dosage be causing the rapid decline? Could he recover some ground if treatment were changed now? I really need some input? My mother is not handling this well and things are deteriorating so quickly that I fear drastic measures on her part may be taken soon! His doctor is in Oklahoma City and my mom would be willing to go anywhere in Texas or Oklahoma to get him to someone who can help improve his condition. Needless to say they have lost faith in both of the doctors that they have seen in Oklahoma City. Thanks for the vent and any information or suggestion will be appreciated. Virginia Herd