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Virginia Herd, [log in to unmask] wrote: "He takes 3 Sinemet CR 50/100 each day, and 1 Eldepryl 5mg each day. He also takes Relaphen (arthritis), Maxzide (meneire's) and Lozal [spelling?] (circulation)." in regard to her father recently diagnosed, but more recently declared rapidly declining. Medication response is one indication of PD. i.e., the benefit from Sinemet would indicate PD. She did not elaborate about initial symptoms and patient improvement. Was there this occurrence? The 50/100 CR referenced is not existent: CR comes 25/100 or 50/200. Was there experimentation in dosage to establish minimum that gave good result? Why was Eldepryl added? I seem to read betwen the lines that anxiety is dominating this man and that he is over-medicated rather quickly with potential that he is afraid to the extent that he is anactive, depressed, and anxious but not communicative. Get him to a specialist Parkinsonian neurologist and talk about anxiety of all concerned. Reduced medication may be worth trying, - even a drug holiday under close observance. Does he sleep at night? I do not know what the other medications effects might be. What do l-dopa and seligiline (Eldepryl) do to Meniere's symptoms? These are conjectures of an educated parky trying to help. A support group might help daughter, mother and father-patient. My limited experience, but widespread reading has not shown this rapid a decline except for MPTP or other toxic exposure - not normal PD. Ron <[log in to unmask]> Ronald Vetter