The following was sent out to the NurseRes list. I wondered if anyone from this list would be able to reply to it. ________________________________________________________________________ _______________________________________________________________________ Date: Sun, 18 Jun 1995 20:29:52 EDT From: Chen Run-sheng <[log in to unmask]> Subject: <No subject given> ----------------------------Original message---------------------------- ----------------------------Original message---------------------------- SOS!!! Dear sir/madam This is Beijing, P. R. China. A woman, Sirou Zhang, has devoted all her life to teaching in China, a developing country, and she is still standing in the classroom. She loves her lovely pupils and all of them couldn't leave their respective "Grandma". But now she has become very sick and is dying. The illness is very rare. Though they have tried their best, doctors at the the best hospitals in Beijing cannot cure her; may do not even know what illness it is. So now we are asking the world---can somebody help us? This is a description of the illness: Our "Grandma" is a 62-year-old right-handed woman complaining of 4 months history of progressive weakness of her extremities. She first developed weakness of right lower limb 4 months ago. And weakness spread to the right upper limb then to the left lower limb in the following two months. She could't climb up stairs without help and walked with a walkstick during the early month. About 3 weeks before she was admitted to hospital, she felt that her voice was lower and her speech became slow and choked sometimes. And she had to leave her lovely pupils. She lost her weight for 4kg during the 4 months. She has no history of difficulty in urination and bowel movement. She was a thin woman and fully alert and oriented. Vital sign and general physical findings were almost normal. A neurological examination shows significantly asymmetrical limb weakness especially in right limbs, slightly decreased tone in the four limbs, loss of sensation at the level of T4 and a glove-stocking anethessia. The cranial nerves examinations showed only one abnormal finding that her tongue to the left. The vibration and joint positional sensation are normal. Reflexes are symmetrical and brisk. There is no signs of damage of cerebellam and pyramidal tract. Laberatory: Full blood cell count, electrolyte levels and liver, kidney, cardiac function are normal. The following laberatory are normal: serum anti-nuclear antibody, anti-smooth muscle antibody, anti-DNA, RF, ASO. T4, T3, TSH, CEA, AFP, and urinay Bence-Jones Protein. Among the serum immunoglobulins IgM level 432Iu/ml was slightly higher compared with the normal range from 66 to 279Iu/ml (repeat value of 361 IU/ml). Serum CK once was higher but normal latter.The repetitive low-freguency electical stimulation showed amplitode of waves decreased gradually for 48%. EMG (electromyogram) showed signs of neurogenous disease demage. The chest X-ray, an abdoment B-ultrasomic examination and the cerviel and cranio cerebral MRI were normal.A lumber puncture was performed and the cerebrospinal fluid pressure was 50mmH20, with a protein level 50mg/dl. Immuno- globulins synthetic rate of serum and CSF are nomal. The CSF and blood gluose concentrations were 49mg\dl and 121mg\dl, respectively. GI was negative. Two dimensional echocardiography was nomal. If you have heard of patients with similar symptom, or have any ideas as to what this illness could be, Please contact with us. We were her students before and we are disparate to help our deeply loved teacher. Please help us! Our E-mail address: [log in to unmask] or [log in to unmask] Please send back E-mail to us! We will send more complete description of her illness to you. Thank you very much National lab of Biomacromelecules Inst. Biophys. Beijing 100101 P.R.China June 16th, 1995