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Jeffrey, I take sinemet 10/100's plus a CR at bedtime, and it works pretty well to help me sleep. By the time the day's 10/l00's stop working, the CR kicks in. Last night, however, I had a problem because the 10/100's kicked in late. I had been "off" most of the evening, and since the medcation got a late start, it overlapped with the CR and I was overmedicated during the night and unable to sleep because of that. You could have the same problem in the morning; timing is tricky. Why not give it a try and see if you can work it out? Pat P.S. My neurologist wasn't very helpful when I asked when the CR would begin working; he says it's different for everyone.