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Re: "kick start" from regular Sinemet-- Peter has been trying this, one way or another, but not long enough to make a recommendation. He got the idea from others on this list, and when we asked his neurol.about it, the reply was that "Most of my patients do that." Another possibility is to use a "booster" dose in the evening, and take the last CR later, at bedtime, so the effecxt lasts through the night better. Good luck. The Flintermanns, Oxford,OH