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Jeffry, your query about adding a 10/100 l-dopa/c-dopa tablet to a Sinemet CR 50/200 elicits some comments. The staatement that regular formulation gets into the brain quicker is not accurate exactly. The CR starts dissolving very quickly. It may be absorbed in the pathway to the stomach even, but it is released in small amount/time. The rate limiter is the dissolving rate of the tablet. The regular tablet is apparently more or less completely dissolved in a few minutes in the stomach, but it is not taken into the blood stream significantly until it passes into the small intestine as part of the chyme (food that is digested) as that material is "pushed" or flows out of the stomach. Here, the rate limiting process is the movement of the medication into the small intestine where more uptake into the blood stream is available. The primary stomach process is dissolving and breaking down food. The majority of the extraction of nutrients is done downstream. If you wish to not increase your total daily dose, try one-half a 50/200 along with a 10/100 each morning. I agree with your goal to use only as much medication as needed. I think this would also keep the carbidopa dosage lower. One other comment is that the fat and protein lumps of meat take a long time to digest, so these are best used minimally with the medications. I would like to hear more from Joe Irr and DuPont about the expected or conjectured or measured locus with time after ingestion of the CR tablet. Does it pass through the stomach into the small intestine substantially whole? if the person has not eaten much recently? remain in the stomach? Joe did state in one of his welcome postings that food does not affect the CR medication. I can assume that this might mean it is little affected bythe digestion "juices" in regard to increasing it's dissolving rate. Comments from any source are solicited by.. Ron <[log in to unmask]> Ronald Vetter