Dear David Boots, I think that's a lot of Sinemet that your neurologist is prescribing. After I got up to about 5 of 25/100, and the dyskenesias began to appear, my neuro. switched me to permax and we cut way back on the Sinemet. For awhile I had terrific dyskenesia, then after awhile I figured out how to regulate it. Now I break up the Sinemets into crumbs, and take them when I start to go off about every 2 1/2 to 3 hours, along with a permax. Now my daily dosage of Sinemet is 1 1/2 to 2 a day, 8 to 6 to 10 Permax, 2 Eldepryl , and 2 Amantadine. I'm 53, and have had PD since age 35, and I"m doing fine. If you question your doctor's judgement and can't get satisfaction, just switch to another. I've been through at least 6 of them. Now I finally trust one. Hope this is helpful. Claudia Elliott