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This info is taken from Dr. Atkins "Health Revelations" Newsletter... NEW SUPPLEMENT EASES ALZHEIMERS, PARKINSONS People with pd stop trembling, those with ad stop forgetting, and everyone else gets a big boost from fatigue - all with a new natural substance that excites me more than anyother discovery of the past decade. NADH, also called Coenzyme 1, is the stored form of energy in every cell of our bodies, and is now available w/o prescription as a suppllement. Even now, it's more effective vs PD than the standard treatment, L -Dopa , and the only promising therapy I see for heretofore incurable AD. As use & research grow (the 1sts governmentally sanctioned clinical test in the U.S. to begin later this year) I'm convinced it will become standard for alleviating depression, fatigue and even minor mental sluggishness. I was already well-informed about NADH when Jorg Birkmayer, M.D., the world's chief NADH researcher, came to the Foundation for the Advancement of Innovativei Medicine in March. I was even taken aback tho' when Birkmayer, director of Birkmayer Institute for PD Therapy in Vienna, played a video of 3 of his patients before & after NADH therapy. If you've ever watched a pd patient, with arms trembling & head wobbling, shuffle hesitantly across a room, you'll know what we saw on the tape before NADH was administered. Several hours after receiving itm the same people were whon getting up with r elative ease and walking briskly. The only difference was NADH. Since 1988, Birkmayer & his father, Walter Birkmayer, M.D., have used NADH to treat more than 885 people with pd. 80% of them showed moderate to excellent improvement in their disability (Acta Neurologica Scandinavia, 1993; 87 [Suppl146]:32-35). The younger Birkmayery believes that most of theh people who didn't improve had advanced arteriosclerosis that prevented the coenzyme from reaching the brain. Far more important that even the initial improvements is that those people haven't deteriorated at all in the years since NADH treatments began. Most of them have been able to discontinue/decrease use of l-dopa. Until Birkmayer began giving NADH to a small group of people with ad, no glimmer of hope existed in the treatment of this dreaded destroyer of memory. But ad & pd share many biochemical similarities, including an ad-like dementia in later stages of pd On the heels of his initial success, Birkmayer decided to test NADH vs the memory robber. All of the 17 people with ad who received supplements of the coenzyme showed significant improvements on standard memory tests, according to unpublished test results. And for the past 2 yearrs further brain deterioration has been stopped in its tracks. And now for the rest of us. I can't state it any more simply than this: supplements of NADH increase your energy levels. In addition, the evidence so far suggests that NADH will become a safe, commonly used supplement to treat depression and garden-variety memory lapses & concentration difficulties. People with family histories of ad may also want to consider taking NADH to prevent mental deterioration. The case history shown below offers a good example of NADH's benefits & illlustrates a guiding principle in its use: The dose is critical to the result. Based on what's happened with many of my patients who turned to NADH in search of their misplaced energy, people don't start to feel better until they take t he dosage that's right for their own bodies. If you take too little, you won't notice anything. If you take too much, you'll become hyperactive & won't be able to fall asleep easily. If someone doesn't derive an energy boost from an initial tablet every other day, I advise them to gradually up the dose until he/she becomes sleepless or restless, then back off slightly. While NADH (Nicotinamide Adenine Dinucleotide) is one of the critical chemical stages in the process by which our bodies creat energy, this actio is probably not the main reason for its remarkable impace on pd & ad. In the brain, it increases the production of dopamine, the neurochemical responsible for coordination and control of movements. People with pd have damage to a portion of the brain's basal ganglia, which causes a shortage of dopamine. So far, doctors have treated pd with the drug l-dopa, which the body converts to dopamine. However, direct l-dopa therapy usually becomes less effective as the years pass, and it often ends up damaging the brain. So the prognosis for people with pd to date has been fairly grim. NADH, tho', increases the body's own natural production of dopaminen, according not only to Birkmayer, but an independent research team at the U of Paris. In ad, the dopamine increase and a boost in another brain chemical, noradrenaline, combine with NADH's production of energy to somehow protect the neural pathways in the brain, Dr. Birkmayer believes. That puts a stop to further brain damage. The planned clinical trials of NADH, which the FDA is expected to approve this summer with Birkmayer's own patented oral version of the coenzyme, should further unlock some of the secrets of this utterly astounding supplement. CASE HISTORY: Name: Richard Kornblatt Address: White Plains, NY Age: 69 Weight: 201 lbs. Height: 6'2" Blood Pressure: 120/80 Symptoms: lack of concentration, difficulty remembering Background: He came to us suffering from fatigue, depression, memory problems, difficulty concentrating, borderliine high blood pressure, and a long list of aches & pains. High blood pressure & many of the aches & pains were easy to treat, but his other problems were tougher nuts. Eventually, I suggested he see a psychiatrist for his depression. He was put on an anti-depressant - sometimes drugs are necessary. After around a year, the psychiatrist doubled the dose of his antidepressant (Pamelor). He still gets depressed, but not as severely as before, Memory lapses & concentration difficulty remained. Treatment: 2 months ago we took another crack at the memory & concentration problems by putting hiim on NADH. I told him to take one 2. 5 mg pill a day for a week, then raise it to 2 pills, and for the third week, three. Results: Once I upped the NADH dosage to 3/day, something very startling happened: His ability to focus his attention suddenly returned. For most of his life he had been a big reader, but during the previous 4 years w/o losing interest. Now he was able to read with good concentratioin for an hour or more. In addition, his energy improved andn his memory got ssharply better. Wanting to test whether NADH really causes these changes, I asked him to lower dose for a week. The improvement so dramatically gained rapidly diminished. When he resume taking it 3x/day, his concentration & memory again returned. HOW TO GET AND TAKE NADHl If you see a supplement in health food storeso called NAD, don't mistake it for NADH. NAD (Nicotinic Acid Dinucleotide ) doesn't provide for the mental and musculaar kick that comes from NADH (the addition of the "H" which stands for hydrogen, activates the substance). Real NADH, also called reduced NAD, can be purchased w/o prescription, but this pill form patented bby Jorg Birmayer, M.D., under the brand name Enada, is currently only available from one source, Menuco Corp. Phone # is (800) 636-8261. Oral NADH is currently pricey (about $49 for package of 20 2.5 mg capsules). I'm hoping cost will go down as it becomes more widely used. Take it about 30 min before eating. Here are my suggestions for how much you should take: (general memory enhancement): start with 1 tablet every other day. if no lift in energy / decrease in fatigue is noticed, take one pill every day. Don't take more than 3/day. (Parkinsons): Typically a physician will give 5-10 mg day in treating pd. Once supplementation begins, you will probably have to lower amount of l-dopa taken, because taking alot of both drug & supplment sometimes causes hyperactivity and increase in muscular movements. Stopping/reducing l -dopa dosages is only safe way to take NADH, so its use M UST be supervised by a doctor. About 1/3 of those with pd will be able to stop using l-dopa entirely according to Birkmayer's research. (Alzheimers): 10 mg/day is standard dosage for people with this debilitating brain disease. THE END (this info was summarized from Dr, Atkins newsletter)