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>I am trying to find anyone who has information on a form of Parkinson's >called Tardive Dyskinesia. It is caused by longterm high dosages of certain >medications such as Stelazine. > Jeff, Tardive Dyskinesia is not a form of PD. In fact it is closely related to the dyskinesia that many of us experience from our L-DOPA. Stelazine and most other drugs found in the category of neuroleptics are dopamine blocking agents. Unfortunately most of these drugs block dopamine in the basal ganglia as well as the other areas of the brain which are involved in the theraputic antipsychotic effect which they exert. When dopamine is blocked for an extended period of time the basal ganglia respond by increasing their sensitivity to dopamine- just as they do in pd patients who endogenously have low dopamine. Eventually the "receptor sites" where the dopamine acts becomes "supersensive" and causes the dyskinesia that both PD patients and TD patients experience. I hope this is useful, Charlie **************************************************************************** ************************************* Charles T. Meyer Madison, WI [log in to unmask] **************************************************************************** ************************************