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Just a short thought on drinking and PD. Alcohol clears the stomach and acts much like sugar. It clears out obstacles in the way and heads straight for the brain. There it is thought to be toxic. Following is my ruined Father's Day last month. At 12:15 PM I was going OFF so I dissolved 1/2 Sinemet 25/250 and drank it down quickly. At 1:00 PM we arrived at Black Angus restaurant. I ordered a Gin and Tonic in a tall glass as I was thirsty. I took 2 or 3 gulps through a straw and within minutes I was in violent dyskinesia. The dyskinesia lasted for about 1.5 hours. I was too exhausted from the dyskinesia to eat the meal. Upon returning home I sleep for about 4 hours only to awake in the OFF state. This is one of the worst dyskinesia states I have ever been in/ I wish it on no one. If the gin didn't kill the neurons, the jerking of my head really shock them up. Regards, Alan Bonander