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Current Science Reviews* July 1995 Joynt, R: JAMA 1995;273:1695-6 (Summary of a 1993 Lancet paper) FD PET scans of 16 sporadic ALS patients show dopamine defect resembling that of PD and possibly Alzheimer's, suggesting related etiology. Also mentions superoxide dismutase anomaly, possibly supporting oxidative-strees hypothesis of ALS and PD. Davie C. et al: J Neur Neurosurg Psy 1995;58:681-687 Proton magnetic resonance spectroscopy of 3 ex-boxers with parkinson syndrome, 6 patients with idiopathic PD, and 6 controls showed reduced N-acetylaspartate in the boxers, suggesting that their syndrome is distinct from that of idiopathic PD. Ostergaard L. et al: J Neur Neurosurg Psy 1995;58:681-687 Injections of apomorphiine (normally an emetic for juvenile poisoning) by single-use pen, which patients can do themselves, in 14 PD patients plus 8 placebo controls, reduced the duration and severity of "off" periods and improved the general feeling of well-being. Du Pont Pharm (ad): J Neur Neurosurg Psy 1995;58 Claims that in tests Sinemet CR didn't prolong "on" time over regular Sinemet, but improved its quality. Korczyn A: Neur 1995;45:1025 Comparison of dementia in PD with that of Alzheimer's seems to show a difference in chemistry. Giladi N: Neur 1995;45:1028 Cyclic menstrual hormone changes profoundly affect PD symptoms and the amount of medication needed. Grafton S. et al: Ann Neur 1995;37:776-783 Post-pallidotomy PET scans of 6 patients showed increased function of motor (voluntary) association cortex as well as the expected reduction of PD symptoms. Good schematic of neural pathways on p. 777. Stephen H. et al: Ann Neur 1995;37:810-814 Three children getting aggressive treatment for leukemia (bone-marrow transplant, high-dose Amphotericin B) developed parkinsonian symptoms and image-confirmed cerebellar, cerebral, and basal ganglia atrophy. *I can do this each month if there is demand for it. J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403