Re query by Roberta Nelson, the following review may help:
Ahlskog et al: Arch Neur 1994;51:1236-1241
After prolonged treatment with levodopa (Sinemet), PD patients develop
fluctuations in symptoms ("on-off effect"). Whether these are due to the
drug or to progression of the disease is uncertain. In a test on 41
volunteers, the long-acting dopamine agonist cabergoline as adjunct
significantly improved motor performance. Effect lasts much longer than that
of bromocryptine or pergolide, permitting administration only once a day,
and it is well tolerated. Further testing is recommended.
(Cabergoline is not yet in PDR '95, but has been in literature since 1988,
as treatment for hyperprolactinemia, and later as a dopamine agonist.)
J. R. Bruman (818) 789-3694
3527 Cody Road
Sherman Oaks, CA 91403
