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Greetings: My husband (age 45) is in a early to mid stage of PD (diagnosed 6 years ago) and currently takes Permax, Eldepryl and Cogentin all at very low doses. His main sympton are arm tremors and slow movement. Although in the total scheme of things his symptons are relatively mild it is becoming more of a nusience and he is considering introducing Sinemet. The doctor has said he would know when he needed more medication and he's beginning to think 'it's time'. Here's our concern - we have only heard terrible things about Sinemet. Most/all messages from this group talk about the negative side effects as does all of our additional research sources. The doctor has said many people take Sinemet for 10 years, do very well on it and suffer little or no side effects. Question for those of you taking Sinemet: How long have you taken it and at what point (1yr, 2 yr...) did side effects become a problem, if ever? We know Sinemet is inevitable (a cure?????) but we're trying to determine if it's wise to delay Sinemet until ABSOLUTELY necessary or are our 'fears' a bit overstated? We appreciate everyone/anyone's response. Parkies are a quiet group and it's tough to get anecdotal information. I also want to thank everyone for all their efforts here. This group is far more helpful to many, many more people than you know. Lot's of us quiet-types out here. Have a great day, L Carper [log in to unmask] --