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To David Boots: The latest issue of the UPF newsletter describes research which seems to implicate Sinemet in a down side in 2 ways: 1) levidopa generates free radicals througout the brain and 2) it contributes to apoptosis (described as "the 'intentional death' of neurons such that once triggered, the neuron initiates a sequence of chemical events that destroys itself". It may be that Sinemet is benificial in the short run but may cause the progression of the PD! A neurosurgeon once told me that Eldepryl is the most overrated drug since laetril. I don't have much confidence in the drugs available for PD. I have an atypical parkinsonism and my symptoms are not affected by Sinemet, so I stopped taking it. I have had PD about 3 yrs and I am not on any medications. So far I am depending upon exercise, a good diet including supplements, adequate rest and simply learning to live with my symptoms by the tricks I have developed. ---Milo Milo V. Anderson, Ph.D. Box 417 Angwin, CA 94508 VOICE 707 965-2508 EMAIL [log in to unmask]