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Allen Trubitt: I have been on Sinemet for l7 months and have had restless leg syndrome for many years before PD. I had mild leg cramps which got progressively worse about a year ago. Lately it is awful. I tried muscle relaxants, anti-seizure drugs, all the health food nostrums for leg cramps, quinine, all the drugstore analgesics, message therapy, hot baths, cold packs, exercise, rest. I was going to try acupuncture but heard from others with severe leg cramps that didn't work. I read a study in Sleep journal that oxycodone (synthetic codeine) l5 mg taken at bedtime works. It did for me but my knees were rubbery all next day. Less dose didn't work. I then tried 5 - 10 mg oxycodene and 50/200 Sinemet CR at bedtime and slept cramp free for 6-7 hours. I usually take about a total of 500 mg Sinemet in 24 hours. I don't like to take that much but I couldn't live with those horrible leg pains. Some people have luck adding either Permax (pergolide) or Parlodel (bromocriptine), which are dopamine agonists, and cutting down on Sinemet. I can't take drugs with ergot in them as I get visual problems (blue light sparklers). Not many doctors (neurologists included) know much if anything about RLS and PD combined. Sometimes a specialist in sleep disorders can help....... Good luck, Barbara Yacos, RN <[log in to unmask]>