Welcome to the list, Norman-- there has been discussion of pramipexole and studies of it which are underway. When you joined the list you were given info re: the archives, where EVERYTHING ever posted is stored and not hard to retrieve if you follow the directions carefully. Recently John Cottingham posted new instructions--if this was before you joined us you can email John for help-- [log in to unmask] I encourage you to use the archives,as they are full of valuable answers to many questions. Hope you find the list helpful to you and your wife. Camilla Flintermann, Oxford,OH