I have been monitoring the correspondence of this group for a short while, as my mother has Parkinson's. I must say the information has been enlightening. We have also prepared and mailed letters to the Wisc. senators. My mother is 85 and was diagnosed with PD 3 years ago. She does not have much tremble (only slight in the arm) but she has difficulty getting her walking movements started and has poor balance. She fell several years ago and broke a hip...and has been more anxious ever since. The medications she is taking are listed below. Since these drugs don't seem to be doing much to help her get movement started at this point, I want to try sinemet with her again. (Note, she also sleeps a lot in the afternoon....I wonder if this is a side effect of one or more of the drugs below....or just a side effect of her senior age.) She had trouble taking sinemet in the beginning....with unacceptable nausea...but since she was never given particularly clear advice on taking it, I think incorrect medication timing and interaction with the wrong foods may have been the problem. (for example, she was not told to take the pills 1/2 hour before or after meals and she was not warned of milk products...etc...I'm surprised the medical community does not seem to have a nice informative handout on "how to start" what appears to be a fairly complex medication program). Currently, she is taking the following medications (note, she is physically small....100-105lbs) : - Parlodel....7.5-10 mg/day ... 2.5mg tablets, 3 to 4 times/day. - Eldepril(Selegiline) ...10mg/day...5mg tablets twice/day. - Amantadine was just discontinued...she had been taking one 100mg capsule/day....It also should be noted that this medication had caused some problems. It had been twice increased to two capsules (200 mg) by the doctor and created significant confusion, (ie she couldn't even tell what day it was), and instability was considerably more pronounced (she fell several times...during periods when the dose was increased). She also has some purple skin blotches on her arms that have sometimes opened up and may be from this drug, based on my reading reports on this net. With regards to other medicines, she has been prescibed and is taking: - Persantine...75 mg/day for heart/blood pressure ?? - Dyazide...37.5/25...twice a week to prevent a reoccurrence of a leg swelling edema 3 months back (this may have been caused by the Amantadine too.) - K-Dur/Potassium...10 mEq to replace salts lost to to dyazide ?? - Ferrous Sulfate...650 mg/day to add iron....diagnosed as anemic - Zantac...150 mg/day....not sure what this is for.....If its a stomach antiacid...will it cause problems with Sinemet ?? - Ascription...1 tablet/day....?? Aspirin product...possibly prescribed as a coronary protective We also recently started her on some vitamins: - 1500 mg of C, 100 mg of B-1, 400IU of E To start her on Sinemet again, she has been prescribed to take 1/2 of a CR 25/100....two times each day along with a 25 mg Lodosyn (carbidopa) tablet, if necessary to eliminate nausea. Other than the discontinued amantadine, she is apparently supposed to continue the other medications. I would appreciate any advice on getting her started on Sinemet and have the following questions: - Is a total of one tablet a day enough ? It doesn't seem so, based on my reading. Does anyone see any problems, cautions, or interactions with the other medications ? - When is the best time to take the medicine and how long between doses ? - Is Nausea really a problem if the sinemet is taken well before a meal ? - What makes a good breakfast ? If a muffin is made using milk, is it off limits ? What kinds of cereal ? Is toast or bread with jam a problem ? - What makes a good lunch ? - My mother likes sweat foods...cookies, cakes, pies, etc. (I know too much is not good...but its tough to change at 85) How restrictive should she be, if the medicines are to be useful ? - It seems that all vegetables and fruits are good. What about salad oils ? butter ? (I assume cottage cheeses, mayonnaise, etc are out due to milk base ?) - What foods are considered high protein...and are these off limit ? If you want to eat some high protein foods or ice cream...is it best to eat at night...say have the medication at 5:00 and eat at 6:00 ?.....or eat earlier and have some final medication before sleep ? - What side effects does Sinemt have ? It seems I've read that it causes sleep problems ?? Thank you all for your continued help and advice. Best Regards, Mike Salter ([log in to unmask])