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On Thu, 27 Jul 1995 12:56:27 Don Voegeli <[log in to unmask]> wrote: > ...I get nervous restlessness while sitting. It usually starts > momentarily in my arms and then moves to one leg, most often the > right. It stays for about 30-40 minutes but has sometimes lasted > almost 2 hours. > ... > Anyone have the same problem and/or answers? Thanx. Don, I had the same problem. The mechanism of restless legs is still not fully understood. Some think is is a delayed side effect that appears after a couple of years on Sinemet while others (including me) think that it is actually a delayed withdrawal symptom. Anyway, for me the cure turned out to be another PD medication. A year and a half ago I started taking Pramipexole, a trial dopamine agonist. Within two weeks my restless legs symptom disappeared. (Even though the study is placebo controlled double blind I am certain I was getting the real stuff). When I transitioned from phase I to phase II (long term study) I had to be titrated off and then back on over a four week period. My restless legs came back while I was off the Pramipexole then once more dissapeared when I went back on. Since phase II usually takes at least three years, I doubt if you would be able to get Pramipexole, but one of the other dopamine agonists currently available may have the same benefical side effect. I also have low BP as a result of the medication. In fact my doctor tells me to eat more salt! Bruce ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Bruce G. Warr "Experience is what enables us to recognize Healthcare Informatics Lab a mistake the next time we make it." Information Systems Dept. University of Maryland Baltimore County http://umbc.edu/~warr/ (V) (410)455-3206 (F) (410)455-1073 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~