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I just joined the list and the next day someone describes my major problem. Now that I am on Sinemet CR (25/100) I have the periodic twitch as the medication wears off. Dr. says he thinks it is withdrawal from Sinemet and also has me starting a dopmine agonist called Permax. I am gradually trying to increase from .05 mg to 3 but my BP drops below 100/60 and I get very weak, etc. exercising becomes more difficult. Have difficulty sleeping. Hope the Permax will eventually help. Also take Eldepryl. Let's keep in touch. Fred