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Hi Donna, I take 500 mg of Tyrosine in the morning and afternoon If I feel a depression coming on which I have not been able to relieve with other techniques such as meditation, breathwork, energy balancing, etc. I try anything which works and helps me to avoid pharmaceuticals. I'm not against their use, but I feel they are the option of last resort. I have had PD for 12 years and am 40 now, so when I consider taking a drug I look at the potential consequences of taking it for the next 30 years. Tyrosine should be taken on an empty stomach and has no affect on L-Dopa absorption.