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Hello Joyce. I read with interest your note on behlf of your mom but saw you mention PD PLUS. I have PD for the past 11 years, keep reading all I can but never saw THAT expression. I also use Sinemet and I would be interested in know the daily dosages and time schedule between each dose. I have learned to ;tweek; the Sinemet during the off periods which certainly helps. good luck and stay in touch via email JOYCE44 or here on the list. JOYCE