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Here in the middle of week 2 of the non-placebo unblind one person NADH study you all will be happy to hear that so far I haven't experienced any irreversible damage that I am aware of. But I will tell you that NADH is some strong stuff....I finally have cut back from the 2 tablets daily recommended by Menuco's literature, to the one per day they suggest for "energy", and frankly I think I may settle in at one every other day. Yesterday, at my husband's insistence, I skipped the day (no NADH), and finally by comparison we got a pretty good feel for what the stuff does. First off, it seems to last a long time in the system, kind of like a good agonist, and definitely boosts the action of the Sinemet. I still have been unable to determine what is the right dose of my 25/100 CR....but a whole tab is TOO MUCH and I have spent the last 9 days in a dyskinetic frenzy. It's exhausting. The NADH also adds to the sleep problem- I didn't think it was possible to have any worse sleep habits than I already did, but unfortunately it is. I felt "rode hard and put up wet" as my old counselor used to say. A real personality enhancer. The good news is that I am sure I can reduce my Sinemet intake, and eventually I will figure out the balance. I noticed that I was moving more fluidly, even when off, waking up, telling hubby that I don't have PD today!! Feel like hell from lack of sleep, but don't have PD. This morn I was back to the regular stiff jerkiness since I abstained from NADH yesterday. The really good news (for some) is a sharply increased interest in things passionate. In retrospect, I think I would call it a zest, or even obsession. You get my drift here. The Menuco literature includes a questionnaire to fill out having to do with frequency (of consumption). The choices offered are: once a day, more than once a day, every two days, once a week, other. This leads me to believe that they are aware that daily consumption may not be for everyone, certainly not for me. I eagerly await the input of the other Guinea pigs,er, I mean, users. I think the hardest part of the whole experiment has been not having the experience of others to fall back on. Thank God for this support network and the valuable info we glean here! Kathie Tollifson([log in to unmask])