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CRADAs - cooperative research and development agreements. Today my Librarian gave me this article from -- SCIENCE NEWS Vol 148 July 29, 1995 Page 73 Somatix and LBNL established a $3.5 Million 3 yr CRADA last May to test a possible treatment for Parkinson's disease. Before getting involved in the CRADA, Somatix researchers had induced Parkinson's in 25 rhesus monkeys. They then inserted into the primates' brains genetically engineered cells that overproduce an enzyme which promotes the production of dopamine, a neurotransmitter, explains EDward Lanphier of Somatix. The new cells should boost patients' production of the neurotransmitter. Last year, after the monkeys got their new cells, LBNL SCIENTISTS monitored the animal's dopamine production with both positron emission tomography (PET) and singlephoton computed tomography scanning devices. The treatment looked so promising that the company hopes to start human trials next year. I have a great librarian, he's always finding interesting articles for me. Margie Nestler