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Someone asked the question if there were any references of Cerebral Palsy being linked to Parkinson's. There are several drugs that may cause parkinsonian like side effects but subside when withdrawn from the offender. Both Reglan and Compazine have been reported to have done this under certain conditions <1> Authors Nygaard TG. Waran SP. Levine RA. Naini AB. Chutorian AM. Institution Department of Neurology, Columbia University College of Physicians & Surgeons, New York, New York. Title Dopa-responsive dystonia simulating cerebral palsy. Source Pediatric Neurology. 11(3):236-40, 1994 Oct. Abstract Five patients presented in infancy or early childhood with various combinations of pyramidal and extrapyramidal signs with normal cognitive function. Their perinatal courses were unremarkable. In each patient, initial impressions listed by several examiners included spastic diplegia or cerebral palsy. Later in each course, either extrapyramidal features or progression suggested dopa-responsive dystonia. In 4 of the 5 children, cerebrospinal fluid was obtained and disclosed reduced levels of biopterin, neopterin, and homovanillic acid in all 4. Levodopa therapy resulted in prompt improvement with normal function returning within 6 months. The disappearance of the "spasticity," extensor plantar responses, and extrapyramidal signs, following levodopa therapy, confirmed the diagnosis of doparesponsive dystonia in these patients. Three had apparently sporadic disease; the other 2 were siblings with an affected paternal grandmother. Three had onset in infancy with delayed sitting and walking before the appearance of overt dystonia; infantile onset is infrequent in dopa-responsive dystonia. The other 2 had normal milestones, but developed gait disorders with prominent imbalance in early childhood. The diagnosis of dopa-responsive dystonia should be considered in children with unexplained or atypical "cerebral palsy." Entry Month 9506. Entry Week: 95063. <2> Authors Factor SA. Matthews MK. Institution Department of Neurology, Albany Medical College, NY. Title Persistent extrapyramidal syndrome with dystonia and rigidity caused by combined metoclopramide (REGLAN) and prochlorperazine (COMPAZINE) therapy. Source Southern Medical Journal. 84(5):626-8, 1991 May. Abstract We have reported the case of a 58-year-old woman with cerebral palsy who experienced a persistent, generalized syndrome of dystonia and rigidity (tardive dystonia-parkinsonism) while being treated for vomiting with metoclopramide in combination with prochlorperazine. This syndrome was more severe than is typically seen in drug-induced extrapyramidal syndromes and may have contributed to her death. The extreme severity of this disorder was probably related to the use of a combination of dopamine antagonists in a patient who had premorbid cerebral dysfunction. Although dopamine antagonists should always be used with caution in individuals with cerebral dysfunction, this particular combination of antiemetics should probably be avoided in such patients. Entry Month 9108. John Cottingham "KNOWLEDGE is of two kinds: we know [log in to unmask] a subject, or we know where we can OR find information upon it." [log in to unmask] Dr. Samuel Johnson