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Mark, Zofran (Ondansetron) is a medication on the market used for nausea in those receiving chemotherapy. So far, there is only one publication about it (from Israel) and they tried it on 16 patients with "moderate to remarkable results"(the Authors). We at Mount Sinai intend to start a study to test it. If this works it would be a significant addition to PD treatment since all antipsychotic medications (except clozapine) worsen PD's motor symptoms. Hope this is helpful Rami ============================================= Rami Kaminski MD The Mount Sinai Medical Center New York