Hello. I've come on-line a week ago and I'm happy to know you all. My name is Doris. When I first became aware of having Parkinson's Disease (about 2 years ago) I could not understand the "on-off" phenomenon because I had no trouble moving, no freezing, no rigidity. (Of course without medication I did have symptoms of P.D. i.e. mask-like face, and non-swinging arms.) But now I realize that my "on-off" phenomenon is this: By the time I am scheduled to take another dosage of the medication, in fact even before, I feel nauseated, I have internal tremors, my throat begins to ache, I feel very fatigued, and I feel very hungry. I now consider these symptoms as my "off" phase. Does anyone else share these somatic symptoms. My dosage is Sinemet 25/100 CR 1/2 tablet 3X per day Sinemet 25/100 1 tablet 3X per day Eldepryl 5mg 1 tablet per day. Thank you for your help. Doris