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I am going on vacation for about two weeks. I will do my best to stay away from this board. I want to see if there is something like withdrawal problems. I tried something last night that worked so good I thought as a parting shot I would ask others to try it the same way I do. This is what was suggested to me. For those who have been on levodopa /carbidopa therapy for many years (11 years for me), it was suggested to take 50 mg or 100 mg of Vitamin B6 at night. The logic is that carbidopa gets rid of B6 so that B6 will not convert Levodopa to dopamine outside of blood-brain-barrier. After many years of this therapy there may be a B6 deficiency or something like that. Thus by adding some at night, it can be most effective. 50 mg to 100 mg is all one needs. This morning when I got up, I felt so GOOOOOOOD. I wanted to shout how great things were. I have not felt that great since before PD. I looked up what a deficiency of B6 might cause and saw <<< DEPRESSION >>>. Well I am off to a vacation. I will be in Providence, RI visiting my son and in Boston visiting my sister. I like warm, dry days and cool evenings. I hope the East Coast accommodates. Notes: Thanks David for your reply. I might add a one-liner for you: "What is life? It is a sexually transmitted terminal disease." For Eric, I took the opportunity to talk about excess medication and caregiver abuse. I knew it didn't apply totally to you. I do not like to see caregiver abuse. When that happens, it is important to seek medical help. The disease does strange things to us. Adding meds is sometimes amateur night at "drug city". But do not allow abuse to continue. It hurts too much mentally. Eric, you have a wonderful mother. If you can bottle her devotion to your father, she would be a rich lady. Don't let her burn out. Bye Alan