Hello. My name is Doris. I came on line a week ago and I am glad to know you all. About two years ago, when I first became aware of having Parkinson's Disease, I did not understand the "on-off" phenomenon because I had no motor problems - no freezing, no body rigidity, no difficulty in getting up and down. Without medication however the symptoms of PD that I had were a masklike face and nonswinging arms when I walked. But now I realize that my particular, peculiar "on-off" phenomenon is this: by the time I am scheduled to take another dosage of the medication, in fact even before, I feel nauseated, my stomach aches, I have internal tremors, my throat feels sore, there is tickling and irritability in my upper chest, I feel very fatigued and extremely sleepy about 1 1/2 hours after taking the medication. I now consider the above symptoms as my "off" phase. My "on" phase is that after taking the medication these symptoms disappear and I feel relatively better for a while - a feel of being all-together. Does anyone else share these somatic symptoms? My dosage is Sinemet 25/100, 1/2 tablet, 3 X per day Sinemet 25/100 CR, 1 tablet, 3 X per day Eldepryl 5mg, 1 tablet per day. Thank you for your support. Doris