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Dear Nancy there must be something to being 48 and being a PD'er. I was there...now 51 and carrying this load for 11 years. I was just dispensing my meds when i read what your taking..sure would make my purse lighter to take only your doses.. ready... sinemet 25/100 6/day sinemet cr 2/day permax 17/day parlodel 8/day clozaril 3.5/day but believe it or not this is the best combination I've been on. Just finished a three week totally ON period but good things come to a sudden stop (pardon the pun) with PD and now I drop into OFF times usually after 5 PM. My legs hurt, too heavy to move, toes and feet cramp (sometimes) and difficult to walk. But I say THANK YOU every nite at bedtime....it could have been worse. Im sure we have more in common.stay in touch. Joyce New Jersey