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Sinemet CR has worked well for me for years. I take 1/2 pill at bedtime and the controlled release works predictably & well overnight. Certainly DuPont would not have made it in a "scored" format if the chemicals were not properly distributed, i.e. symmetrically on both sides. If you don't wish to rely on this anecdotal evidence, there's an expert named Joe Irr, who used to frequent this list. I think he is with DuPont Pharma, email: [log in to unmask] William Berman