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Another use for GM-1 ganglioside or LIGA20 and LIGA40? Essential tremor effects 5 times the population found with Parkinson's which might work to encourage more research in the varied uses for these compounds. Since it takes $200 million for a drug company to bring a compound through the trials onto the pharmacy shelves, an increased market is a plus. <1> Authors Ishizaki F. Harada T. Kito S. Harada A. Saeki M. Nakamura S. Institution Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan. Title The effect of bovine brain gangliosides on essential tremor. Source Hiroshima Journal of Medical Sciences. 40(2):83-5, 1991 Jun. Abstract We reported the case of a 74-year-old woman suffering from essential tremor for 20 years which was treated effectively with purified bovine brain gangliosides containing GM1, GD1a, GD1b and GT1b gangliosides. The trials of the treatment were conducted twice, 40 mg and 20 mg gangliosides per day respectively administered intramuscularly. Essential tremor dramatically improved with gangliosides on the second day of treatment, suggesting that the effect of gangliosides was not induced by neuronal sprouting or regeneration. It is speculated that a certain type of essential tremor is a reversible disease of membrane disorder. John Cottingham "KNOWLEDGE is of two kinds: we know [log in to unmask] a subject, or we know where we can OR find information upon it." [log in to unmask] Dr. Samuel Johnson