Ken Aidekman asked me to pass along some information about whether there are problems with the time release properties of Sinemet CR if the tablet is broken in half. The large Sinemet CR tablet (50/200) is scored so it can be broken into two pieces. If done carefully, the slow release characteristics are retained fairly well. However, the drug might reach peak blood plasma levels a few minutes sooner than with the intact tablet. The small tablet Sinemet CR 25/100 is not scored and should not be broken in half unless you are advised to do so by your physician. Whenever you break any tablet in half, whether it is Sinemet or any other medicine, you will alter the pharmacological effects to some extent. For someone who must be very careful with the amount of drug taken and the rate at which it is absorbed into the blood stream and eventually the brain, my advice is to be very careful when breaking a tablet. Discuss the merits of this sort of activity with your physician when next you meet. In the meantime, I wish all of you my very best. I only wish there were not so many sending messages to the list. I cannot keep up any more with the really thoughtful and supportive communications. Best regards, Joe Irr Worldwide Product Manager - the Sinemet Brand